Heritability of hematologic malignancies: From pedigrees to genomics

Jane E. Churpek, Kenan Onel

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Many hematologic malignancies have an underlying heritable component. Although not as well characterized as the acquired genetic abnormalities that define important prognostic and therapeutic subgroups of myeloid and lymphoid neoplasms, investigations are beginning to unravel the role of germline genetic variation in the predisposition to hematologic malignancies. Information gained from the study of striking family pedigrees, epidemiologic data, and candidate genes are now being combined with unbiased genome-wide investigations to outline the network of genetic abnormalities that contribute to hematologic malignancy risk. This article reviews the current understanding of the heritability of hematologic malignancies in the genomics era.

Original languageEnglish
Pages (from-to)939-972
Number of pages34
JournalHematology/Oncology Clinics of North America
Volume24
Issue number5
DOIs
StatePublished - Oct 2010
Externally publishedYes

Keywords

  • Familial
  • Genetics
  • Genomics
  • Leukemia
  • Lymphoma

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