TY - JOUR
T1 - Heritability of head motion during resting state functional MRI in 462 healthy twins
AU - Couvy-Duchesne, Baptiste
AU - Blokland, Gabriëlla A.M.
AU - Hickie, Ian B.
AU - Thompson, Paul M.
AU - Martin, Nicholas G.
AU - de Zubicaray, Greig I.
AU - McMahon, Katie L.
AU - Wright, Margaret J.
N1 - Funding Information:
This study was supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development, USA (Grant RO1HD050735 ), and the National Health and Medical Research Council (NHMRC), Australia (Project Grant 496682 ). Zygosity typing was funded by the Australian Research Council (ARC) (Grants A7960034 , A79906588 , A79801419 , and DP0212016 ). Greig de Zubicaray is supported by an ARC Future Fellowship ( FT0991634 ). Baptiste Couvy-Duchesne was supported by the Region Bretagne (Ulysses grants for internship), the University of Queensland (UQI PhD scholarship) and the Queensland Institute of Medical Research . The content of this paper is solely the responsibility of the authors and does not necessarily represent the official views of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, The National Institutes of Health, NHMRC, or ARC.
PY - 2014/11/15
Y1 - 2014/11/15
N2 - Head motion (HM) is a critical confounding factor in functional MRI. Here we investigate whether HM during resting state functional MRI (RS-fMRI) is influenced by genetic factors in a sample of 462 twins (65% fema≤ 101 MZ (monozygotic) and 130 DZ (dizygotic) twin pairs; mean age: 21 (SD=3.16), range 16-29). Heritability estimates for three HM components-mean translation (MT), maximum translation (MAXT) and mean rotation (MR)-ranged from 37 to 51%. We detected a significant common genetic influence on HM variability, with about two-thirds (genetic correlations range 0.76-1.00) of the variance shared between MR, MT and MAXT. A composite metric (HM-PC1), which aggregated these three, was also moderately heritable (h2=42%). Using a sub-sample (N=35) of the twins we confirmed that mean and maximum translational and rotational motions were consistent "traits" over repeated scans (r=0.53-0.59); reliability was even higher for the composite metric (r=0.66). In addition, phenotypic and cross-trait cross-twin correlations between HM and resting state functional connectivities (RS-FCs) with Brodmann areas (BA) 44 and 45, in which RS-FCs were found to be moderately heritable (BA44: h2-=0.23 (sd=0.041), BA45: h2-=0.26 (sd=0.061)), indicated that HM might not represent a major bias in genetic studies using FCs. Even so, the HM effect on FC was not completely eliminated after regression. HM may be a valuable endophenotype whose relationship with brain disorders remains to be elucidated.
AB - Head motion (HM) is a critical confounding factor in functional MRI. Here we investigate whether HM during resting state functional MRI (RS-fMRI) is influenced by genetic factors in a sample of 462 twins (65% fema≤ 101 MZ (monozygotic) and 130 DZ (dizygotic) twin pairs; mean age: 21 (SD=3.16), range 16-29). Heritability estimates for three HM components-mean translation (MT), maximum translation (MAXT) and mean rotation (MR)-ranged from 37 to 51%. We detected a significant common genetic influence on HM variability, with about two-thirds (genetic correlations range 0.76-1.00) of the variance shared between MR, MT and MAXT. A composite metric (HM-PC1), which aggregated these three, was also moderately heritable (h2=42%). Using a sub-sample (N=35) of the twins we confirmed that mean and maximum translational and rotational motions were consistent "traits" over repeated scans (r=0.53-0.59); reliability was even higher for the composite metric (r=0.66). In addition, phenotypic and cross-trait cross-twin correlations between HM and resting state functional connectivities (RS-FCs) with Brodmann areas (BA) 44 and 45, in which RS-FCs were found to be moderately heritable (BA44: h2-=0.23 (sd=0.041), BA45: h2-=0.26 (sd=0.061)), indicated that HM might not represent a major bias in genetic studies using FCs. Even so, the HM effect on FC was not completely eliminated after regression. HM may be a valuable endophenotype whose relationship with brain disorders remains to be elucidated.
KW - Broca's area
KW - Head motion
KW - Heritability
KW - Resting state fMRI
KW - Twin study
UR - http://www.scopus.com/inward/record.url?scp=84906505424&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2014.08.010
DO - 10.1016/j.neuroimage.2014.08.010
M3 - Article
C2 - 25132021
AN - SCOPUS:84906505424
SN - 1053-8119
VL - 102
SP - 424
EP - 434
JO - NeuroImage
JF - NeuroImage
IS - P2
ER -