@inproceedings{33597a2c9c01465cb2c0d6b7e6011e22,
title = "Heritability of brain network topology in 853 twins and siblings",
abstract = "Anatomical brain networks change throughout life and with diseases. Genetic analysis of these networks may help identify processes giving rise to heritable brain disorders, but we do not yet know which network measures are promising for genetic analyses. Many factors affect the downstream results, such as the tractography algorithm used to define structural connectivity. We tested nine different tractography algorithms and four normalization methods to compute brain networks for 853 young healthy adults (twins and their siblings). We fitted genetic structural equation models to all nine network measures, after a normalization step to increase network consistency across tractography algorithms. Probabilistic tractography algorithms with global optimization (such as Probtrackx and Hough) yielded higher heritability statistics than 'greedy' algorithms (such as FACT) which process small neighborhoods at each step. Some global network measures (probtrackx-derived GLOB and ST) showed significant genetic effects, making them attractive targets for genome-wide association studies.",
keywords = "Brain Network, ICC, Normalization, Tractography, diffusion MRI",
author = "L. Zhan and N. Jahanshad and J. Faskowitz and D. Zhu and G. Prasad and Martin, \{N. G.\} and \{De Zubicaray\}, \{G. I.\} and McMahon, \{K. L.\} and Wright, \{M. J.\} and Thompson, \{P. M.\}",
note = "Publisher Copyright: {\textcopyright} 2015 IEEE.; 12th IEEE International Symposium on Biomedical Imaging, ISBI 2015 ; Conference date: 16-04-2015 Through 19-04-2015",
year = "2015",
month = jul,
day = "21",
doi = "10.1109/ISBI.2015.7163908",
language = "English",
series = "Proceedings - International Symposium on Biomedical Imaging",
publisher = "IEEE Computer Society",
pages = "449--453",
booktitle = "2015 IEEE 12th International Symposium on Biomedical Imaging, ISBI 2015",
address = "United States",
}