Hereditary episodic ataxias

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

50 Scopus citations

Abstract

Hereditary episodic ataxia (EA) syndromes are rare monogenic disorders that are phenotypically and genetically heterogeneous. The number of identified EA phenotypes is expanding. So far, mutations have been identified in four genes, all coding for membrane proteins including ion channels and transporters. The study of EA has illuminated previously unrecognized but important roles of ion channels and transporters in cerebellar function. This review summarizes recent advances and focuses on practical approaches in the diagnosis and treatment of episodic ataxia.

Original languageEnglish
Title of host publicationThe Year in Neurology 2008
PublisherBlackwell Publishing Inc.
Pages250-253
Number of pages4
ISBN (Print)9781573317306
DOIs
StatePublished - Oct 2008
Externally publishedYes

Publication series

NameAnnals of the New York Academy of Sciences
Volume1142
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • Channelopathies
  • Episodic ataxia
  • Genetic

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