HER2 codon 655 polymorphism and breast cancer: Results from kin-cohort and case-control analyses

Robert C. Millikan, Amanda J. Hummer, Mary S. Wolff, Asahi Hishida, Colin B. Begg

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Several published epidemiologic studies show increased breast cancer risk for carriers of the Val-allele at codon 655 of the HER2 gene. We conducted additional analyses using data from three studies, including case-control analyses stratified on age and kin-cohort analyses using relatives of cases and controls. The results provide additional evidence that HER2 codon 655 genotype may predispose to early-onset breast cancer.

Original languageEnglish
Pages (from-to)309-312
Number of pages4
JournalBreast Cancer Research and Treatment
Volume89
Issue number3
DOIs
StatePublished - Feb 2005
Externally publishedYes

Keywords

  • Breast cancer
  • Genetics
  • HER2 polymorphism

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