Hepatosplenic γδ T-cell lymphoma: An overview

Koppany Visnyei, Michael L. Grossbard, Ilan Shapira

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


Peripheral T-cell lymphomas are a heterogeneous group of lymphoid malignancies. Among these, hepatosplenic γδ T-cell lymphoma (HTCL) represents an aggressive and treatment-resistant subgroup for which new avenues of treatment are critically needed. HTCL is characterized by primary extranodal distribution of the malignant cells with typical intrasinusoidal infiltration of the liver, spleen, and bone marrow, which results in hepatosplenomegaly and peripheral blood cytopenias. Another characteristic feature is the expression of γδ T-cell receptors. HTCL exhibits a rapid progressive course and an extremely poor response to currently known therapeutic strategies, with a 5-year overall survival rate of only 7%. In this review, we discuss the clinical, pathologic, and molecular characteristics of this disease, along with the challenges that are associated with its diagnosis and treatment.

Original languageEnglish
Pages (from-to)360-369
Number of pages10
JournalClinical Lymphoma, Myeloma and Leukemia
Issue number4
StatePublished - Aug 2013
Externally publishedYes


  • Allogeneic transplantation
  • Autologous transplantation
  • CHOP
  • Hyper-CVAD
  • T-cell receptor
  • TCR


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