Hepatoprotective effects of S-adenosyl-L-methionine against alcohol- and cytochrome P450 2E1-induced liver injury

Arthur I. Cederbaum

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

S-adenosyl-L-methionine (SAM) acts as a methyl donor for methylation reactions and participates in the synthesis of glutathione. SAM is also a key metabolite that regulates hepatocyte growth, differentiation and death. Hepatic SAM levels are decreased in animal models of alcohol liver injury and in patients with alcohol liver disease or viral cirrhosis. This review describes the protection by SAM against alcohol and cytochrome P450 2E1-dependent cytotoxicity both in vitro and in vivo and evaluates mechanisms for this protection.

Original languageEnglish
Pages (from-to)1366-1376
Number of pages11
JournalWorld Journal of Gastroenterology
Volume16
Issue number11
DOIs
StatePublished - 21 Mar 2010

Keywords

  • Cytochrome P450 2E1
  • Ethanol
  • Oxidative stress
  • S-adenosyl-l-methionine
  • Toxic hepatitis

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