Hepatocellular Carcinoma in a Long‐Term Survivor of Intrahepatic Biliary Duct Hypoplasia

Nancy Bach, Hirschel Kahn, Swan N. Thung, Fenton Schaffner, Franklin M. Klion, Charles M. Miller

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


We describe the development of hepatocellular carcinoma (HCC) in a 46‐yr‐old woman with intrahepatic biliary duct hypoplasia. Her underlying liver disease was quiescent for many years until a dramatic rise in serum bilirubin was seen. Orthotopic liver transplantation was performed, and a large tumor was found during surgery. A bile‐producing HCC was identified, infiltrating about 50% of an otherwise noncirrhotic liver which had a paucity of intrahepatic ducts. The findings of HCC in this long‐term survivor of intrahepatic biliary duct hypoplasia indicates HCC may occur in patients with long‐standing disease.

Original languageEnglish
Pages (from-to)1527-1530
Number of pages4
JournalAmerican Journal of Gastroenterology
Issue number10
StatePublished - Oct 1991


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