Hepatocellular Carcinoma in a Long‐Term Survivor of Intrahepatic Biliary Duct Hypoplasia

We describe the development of hepatocellular carcinoma (HCC) in a 46‐yr‐old woman with intrahepatic biliary duct hypoplasia. Her underlying liver disease was quiescent for many years until a dramatic rise in serum bilirubin was seen. Orthotopic liver transplantation was performed, and a large tumor was found during surgery. A bile‐producing HCC was identified, infiltrating about 50% of an otherwise noncirrhotic liver which had a paucity of intrahepatic ducts. The findings of HCC in this long‐term survivor of intrahepatic biliary duct hypoplasia indicates HCC may occur in patients with long‐standing disease.