TY - JOUR
T1 - Hepatocellular carcinoma
T2 - Genome-scale metabolic models for hepatocellular carcinoma
AU - Pinyol, Roser
AU - Llovet, Josep M.
N1 - Funding Information:
J.M.L. is supported by grants from the European Commission Framework Programme 7 (Heptromic, proposal number 259744), the US National Institute of Diabetes and Digestive and Kidney Diseases (1R01DK076986), the Samuel Waxman Cancer Research Foundation, the Spanish National Health Institute (SAF‑2010‑16055) and the Asociación Española para el Estudio del Cáncer.
PY - 2014/6
Y1 - 2014/6
N2 - A new study proposes a modelling strategy to identify reactions, genes and metabolites relevant in hepatocellular carcinoma using in silico and in vivo analyses. The proposed genome-scale metabolic model integrates genomic and proteomic information, and points to statins, among others, as potential chemopreventive and anticancer drugs.
AB - A new study proposes a modelling strategy to identify reactions, genes and metabolites relevant in hepatocellular carcinoma using in silico and in vivo analyses. The proposed genome-scale metabolic model integrates genomic and proteomic information, and points to statins, among others, as potential chemopreventive and anticancer drugs.
UR - https://www.scopus.com/pages/publications/84901988670
U2 - 10.1038/nrgastro.2014.70
DO - 10.1038/nrgastro.2014.70
M3 - Review article
C2 - 24840704
AN - SCOPUS:84901988670
SN - 1759-5045
VL - 11
SP - 336
EP - 337
JO - Nature Reviews Gastroenterology and Hepatology
JF - Nature Reviews Gastroenterology and Hepatology
IS - 6
ER -