Hepatobiliary Manifestations of Human Immunodeficiency Virus

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


The development of chronic liver diseases in human immunodeficiency virus (HIV)-infected patients is a growing concern. Coinfection with chronic hepatitis viruses is more frequent in the HIV population because of shared routes of transmission and a lower likelihood of spontaneous clearance. Liver injury in the setting of coinfection is accelerated and leads to a higher rate of complications, resulting in increased morbidity and mortality in this population. Antiretroviral therapy (ART) has substantially decreased the incidence of opportunistic infections, although in immunosuppressed HIV-infected patients the liver and biliary tract are frequent sites of infection. HIV infection and long-term ART are associated with metabolic complications, lipodystrophy, insulin resistance, steatosis, and steatohepatitis, which contribute to the increasing burden of liver disease in HIV-infected patients. Hepatocellular carcinoma is an increasing complication of chronic liver disease in these patients. Fortunately, liver transplant is a promising treatment option for HIV-infected patients with end-stage liver disease.

Original languageEnglish
Title of host publicationSchiff's Diseases of the Liver
Number of pages23
ISBN (Print)0470654686, 9780470654682
StatePublished - 31 Oct 2011


  • Antiretroviral therapy (ART)
  • Coinfection
  • HIV
  • Hepatitis B virus (HBV)
  • Hepatitis C virus (HCV)
  • Liver transplantation
  • Opportunistic infections
  • Steatohepatitis


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