Hepatitis delta virus facilitates the selection of hepatitis B virus mutants in vivo and functionally impacts on their replicative capacity in vitro

E. Shirvani-Dastgerdi; M. R. Pourkarim; U. Herbers; S. Amini-Bavil-Olyaee; E. Yagmur; S. M. Alavian; C. Trautwein; F. Tacke

doi:10.1016/j.cmi.2015.09.020

Hepatitis delta virus facilitates the selection of hepatitis B virus mutants in vivo and functionally impacts on their replicative capacity in vitro

E. Shirvani-Dastgerdi
, M. R. Pourkarim
, U. Herbers
, S. Amini-Bavil-Olyaee
, E. Yagmur
, S. M. Alavian
, C. Trautwein
, F. Tacke

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

To identify molecular interactions between hepatitis B virus (HBV) and hepatitis delta virus (HDV), HBV sequences were analysed in HBV/HDV-infected patients. Characteristic amino acid substitutions were found in cytosolic domains of hepatitis B surface antigen (HBsAg), in contrast to HBV-mono-infected controls. The functional impact of HDV on the replication of wild-type and mutant HBV was assessed in vitro. HDV co-transfection significantly reduced the replication of HBV strains containing precore or basal core promoter mutations, and HBV polymerase or surface antigen mutants affected HDV replication in vitro. Conclusively, our study revealed distinct HBsAg mutational patterns in HBV/HDV-infected patients and novel functional interactions between HBV and HDV.

Original language	English
Pages (from-to)	98.e1-98.e6
Journal	Clinical Microbiology and Infection
Volume	22
Issue number	1
DOIs	https://doi.org/10.1016/j.cmi.2015.09.020
State	Published - 1 Jan 2016
Externally published	Yes

Keywords

Basal core promoter
HBsAg
Hepatitis B virus
Hepatitis delta virus
Precore

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10.1016/j.cmi.2015.09.020

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Shirvani-Dastgerdi, E., Pourkarim, M. R., Herbers, U., Amini-Bavil-Olyaee, S., Yagmur, E., Alavian, S. M., Trautwein, C., & Tacke, F. (2016). Hepatitis delta virus facilitates the selection of hepatitis B virus mutants in vivo and functionally impacts on their replicative capacity in vitro. Clinical Microbiology and Infection, 22(1), 98.e1-98.e6. https://doi.org/10.1016/j.cmi.2015.09.020

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title = "Hepatitis delta virus facilitates the selection of hepatitis B virus mutants in vivo and functionally impacts on their replicative capacity in vitro",

abstract = "To identify molecular interactions between hepatitis B virus (HBV) and hepatitis delta virus (HDV), HBV sequences were analysed in HBV/HDV-infected patients. Characteristic amino acid substitutions were found in cytosolic domains of hepatitis B surface antigen (HBsAg), in contrast to HBV-mono-infected controls. The functional impact of HDV on the replication of wild-type and mutant HBV was assessed in vitro. HDV co-transfection significantly reduced the replication of HBV strains containing precore or basal core promoter mutations, and HBV polymerase or surface antigen mutants affected HDV replication in vitro. Conclusively, our study revealed distinct HBsAg mutational patterns in HBV/HDV-infected patients and novel functional interactions between HBV and HDV.",

keywords = "Basal core promoter, HBsAg, Hepatitis B virus, Hepatitis delta virus, Precore",

author = "E. Shirvani-Dastgerdi and Pourkarim, \{M. R.\} and U. Herbers and S. Amini-Bavil-Olyaee and E. Yagmur and Alavian, \{S. M.\} and C. Trautwein and F. Tacke",

note = "Publisher Copyright: {\textcopyright} 2015 European Society of Clinical Microbiology and Infectious Diseases.",

year = "2016",

month = jan,

day = "1",

doi = "10.1016/j.cmi.2015.09.020",

language = "English",

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Shirvani-Dastgerdi, E, Pourkarim, MR, Herbers, U, Amini-Bavil-Olyaee, S, Yagmur, E, Alavian, SM, Trautwein, C & Tacke, F 2016, 'Hepatitis delta virus facilitates the selection of hepatitis B virus mutants in vivo and functionally impacts on their replicative capacity in vitro', Clinical Microbiology and Infection, vol. 22, no. 1, pp. 98.e1-98.e6. https://doi.org/10.1016/j.cmi.2015.09.020

TY - JOUR

T1 - Hepatitis delta virus facilitates the selection of hepatitis B virus mutants in vivo and functionally impacts on their replicative capacity in vitro

AU - Shirvani-Dastgerdi, E.

AU - Pourkarim, M. R.

AU - Herbers, U.

AU - Amini-Bavil-Olyaee, S.

AU - Yagmur, E.

AU - Alavian, S. M.

AU - Trautwein, C.

AU - Tacke, F.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - To identify molecular interactions between hepatitis B virus (HBV) and hepatitis delta virus (HDV), HBV sequences were analysed in HBV/HDV-infected patients. Characteristic amino acid substitutions were found in cytosolic domains of hepatitis B surface antigen (HBsAg), in contrast to HBV-mono-infected controls. The functional impact of HDV on the replication of wild-type and mutant HBV was assessed in vitro. HDV co-transfection significantly reduced the replication of HBV strains containing precore or basal core promoter mutations, and HBV polymerase or surface antigen mutants affected HDV replication in vitro. Conclusively, our study revealed distinct HBsAg mutational patterns in HBV/HDV-infected patients and novel functional interactions between HBV and HDV.

AB - To identify molecular interactions between hepatitis B virus (HBV) and hepatitis delta virus (HDV), HBV sequences were analysed in HBV/HDV-infected patients. Characteristic amino acid substitutions were found in cytosolic domains of hepatitis B surface antigen (HBsAg), in contrast to HBV-mono-infected controls. The functional impact of HDV on the replication of wild-type and mutant HBV was assessed in vitro. HDV co-transfection significantly reduced the replication of HBV strains containing precore or basal core promoter mutations, and HBV polymerase or surface antigen mutants affected HDV replication in vitro. Conclusively, our study revealed distinct HBsAg mutational patterns in HBV/HDV-infected patients and novel functional interactions between HBV and HDV.

KW - Basal core promoter

KW - HBsAg

KW - Hepatitis B virus

KW - Hepatitis delta virus

KW - Precore

UR - https://www.scopus.com/pages/publications/84959270151

U2 - 10.1016/j.cmi.2015.09.020

DO - 10.1016/j.cmi.2015.09.020

M3 - Article

C2 - 26433026

AN - SCOPUS:84959270151

SN - 1198-743X

VL - 22

SP - 98.e1-98.e6

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

IS - 1

ER -

Hepatitis delta virus facilitates the selection of hepatitis B virus mutants in vivo and functionally impacts on their replicative capacity in vitro

Abstract

Keywords

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