Hepatitis C virus treatment in HIV-coinfected patients: No longer different from monoinfection treatment

Bevin Hearn, David Delbello, Joseph Lawler, Michel Ng, Alyson Harty, Douglas T. Dieterich

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Between 15% and 30% of patients infected with HIV in the United States and Europe are coinfected with hepatitis C virus (HCV), and rates of acute HCV infection have been increasing in some populations of HIV-positive patients. Liver disease is now a leading cause of death in HIV-infected patients. Patients with HIV/HCV coinfection have lower rates of spontaneous acute HCV clearance, poorer response to treatment of chronic HCV in the pre-direct-acting antiviral era, more rapid progression to cirrhosis, and increased risk of hepatocellular carcinoma. This article will summarize data on management of HIV/HCV coinfection, discuss the epidemic of acute HCV infection in HIV-infected patients, and examine the many new HCV treatment regimens on the horizon with data on coinfected patients.

Original languageEnglish
Pages (from-to)706-715
Number of pages10
JournalGastroenterology and Hepatology
Volume10
Issue number11
StatePublished - 1 Nov 2014

Keywords

  • Acute hepatitis C
  • HIV/HCV coinfection
  • HIV/HCV management
  • Hepatitis C virus

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