Hepatitis B—management of acute infection and active inflammation in pregnancy—a hepatologist's perspective

Grace Lai Hung Wong; Wan Hsin Wen; Calvin Q. Pan

doi:10.1016/j.bpobgyn.2020.03.014

Hepatitis B—management of acute infection and active inflammation in pregnancy—a hepatologist's perspective

Grace Lai Hung Wong, Wan Hsin Wen, Calvin Q. Pan

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

Women at childbearing age and pregnant ladies living in the areas of high or intermediate prevalence of hepatitis B virus (HBV) remain at risk of getting the infection and passing the infections to their offspring via mother-to-child transmission (MTCT) of HBV. HBV infection may affect the mothers by active hepatitis, very occasionally liver cirrhosis and rarely fulminant hepatitis and liver failure. The virus may be transmitted to the babies despite immunoprophylaxis in the setting of very high maternal viral load. Tenofovir disoproxil fumarate (TDF) has been shown to be efficacious to reduce MTCT of HBV, which contributes to the elimination of chronic HBV infection by 2030, the goal set by World Health Organization.

Original language	English
Pages (from-to)	54-65
Number of pages	12
Journal	Best Practice and Research: Clinical Obstetrics and Gynaecology
Volume	68
DOIs	https://doi.org/10.1016/j.bpobgyn.2020.03.014
State	Published - Oct 2020
Externally published	Yes

Keywords

Acute hepatitis
Chronic hepatitis
Hepatitis B virus
Mother-to-child transmission
Pregnancy
Tenofovir disoproxil fumarate

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10.1016/j.bpobgyn.2020.03.014

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title = "Hepatitis B—management of acute infection and active inflammation in pregnancy—a hepatologist's perspective",

abstract = "Women at childbearing age and pregnant ladies living in the areas of high or intermediate prevalence of hepatitis B virus (HBV) remain at risk of getting the infection and passing the infections to their offspring via mother-to-child transmission (MTCT) of HBV. HBV infection may affect the mothers by active hepatitis, very occasionally liver cirrhosis and rarely fulminant hepatitis and liver failure. The virus may be transmitted to the babies despite immunoprophylaxis in the setting of very high maternal viral load. Tenofovir disoproxil fumarate (TDF) has been shown to be efficacious to reduce MTCT of HBV, which contributes to the elimination of chronic HBV infection by 2030, the goal set by World Health Organization.",

keywords = "Acute hepatitis, Chronic hepatitis, Hepatitis B virus, Mother-to-child transmission, Pregnancy, Tenofovir disoproxil fumarate",

author = "Wong, {Grace Lai Hung} and Wen, {Wan Hsin} and Pan, {Calvin Q.}",

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doi = "10.1016/j.bpobgyn.2020.03.014",

language = "English",

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pages = "54--65",

journal = "Best Practice and Research: Clinical Obstetrics and Gynaecology",

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T1 - Hepatitis B—management of acute infection and active inflammation in pregnancy—a hepatologist's perspective

AU - Wong, Grace Lai Hung

AU - Wen, Wan Hsin

AU - Pan, Calvin Q.

PY - 2020/10

Y1 - 2020/10

N2 - Women at childbearing age and pregnant ladies living in the areas of high or intermediate prevalence of hepatitis B virus (HBV) remain at risk of getting the infection and passing the infections to their offspring via mother-to-child transmission (MTCT) of HBV. HBV infection may affect the mothers by active hepatitis, very occasionally liver cirrhosis and rarely fulminant hepatitis and liver failure. The virus may be transmitted to the babies despite immunoprophylaxis in the setting of very high maternal viral load. Tenofovir disoproxil fumarate (TDF) has been shown to be efficacious to reduce MTCT of HBV, which contributes to the elimination of chronic HBV infection by 2030, the goal set by World Health Organization.

AB - Women at childbearing age and pregnant ladies living in the areas of high or intermediate prevalence of hepatitis B virus (HBV) remain at risk of getting the infection and passing the infections to their offspring via mother-to-child transmission (MTCT) of HBV. HBV infection may affect the mothers by active hepatitis, very occasionally liver cirrhosis and rarely fulminant hepatitis and liver failure. The virus may be transmitted to the babies despite immunoprophylaxis in the setting of very high maternal viral load. Tenofovir disoproxil fumarate (TDF) has been shown to be efficacious to reduce MTCT of HBV, which contributes to the elimination of chronic HBV infection by 2030, the goal set by World Health Organization.

KW - Acute hepatitis

KW - Chronic hepatitis

KW - Hepatitis B virus

KW - Mother-to-child transmission

KW - Pregnancy

KW - Tenofovir disoproxil fumarate

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U2 - 10.1016/j.bpobgyn.2020.03.014

DO - 10.1016/j.bpobgyn.2020.03.014

M3 - Review article

C2 - 32340799

AN - SCOPUS:85083636778

SN - 1521-6934

VL - 68

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EP - 65

JO - Best Practice and Research: Clinical Obstetrics and Gynaecology

JF - Best Practice and Research: Clinical Obstetrics and Gynaecology

ER -

Hepatitis B—management of acute infection and active inflammation in pregnancy—a hepatologist's perspective

Abstract

Keywords

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