Hepatic Vitamin A Depletion in Alcoholic Liver Injury

Maria Anna Leo, Charles S. Lieber

Research output: Contribution to journalArticlepeer-review

279 Scopus citations


SYMPTOMS of vitamin A deficiency, such as night blindness and hypogonadism, have been described in alcoholics,1,2 but the relation between alcoholism, serum vitamin A, and hepatic vitamin A is not known. Previous studies of hepatic vitamin A levels in various disease states involved only autopsy material, did not include biopsy data, and did not specify whether the subjects studied were alcoholic.3 4 5 There are some reports on patients with alcoholic cirrhosis who had evidence of a low circulating level of vitamin A,2,6 7 8 but the actual hepatic vitamin A concentrations of these subjects have not been described. Therefore, we undertook a study.

Original languageEnglish
Pages (from-to)597-601
Number of pages5
JournalNew England Journal of Medicine
Issue number10
StatePublished - 2 Sep 1982
Externally publishedYes


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