Hepatic lipocytes: A major target for endothelin-1

C. N. Housset, D. C. Rockey, S. L. Friedman, D. M. Bissell

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations

Abstract

Lipocytes are the predominant target for ET-1 within the normal and fibrotic liver. ET-1-induced contraction of lipocytes becomes prominent in liver injury. In this setting, ET-1 may have an autocrine role in regulating sinusoidal flow, in association with eicosanoids and other endothelium derived factors such as nitric oxide (NO). In more advanced fibrosis, ET-1 may participate in contraction of collagen bands causing distortion of the lobular structure. A direct role of ET-1 in the activation of lipocytes is still hypothetical but could represent additional effects of ET-1 in various stages of liver fibrogenesis via paracrine and/or autocrine routes.

Original languageEnglish
Pages (from-to)55-60
Number of pages6
JournalJournal of Hepatology, Supplement
Volume22
Issue number2
StatePublished - 1995
Externally publishedYes

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