Hepatic fibrosis: Pathogenesis and principles of therapy

E. Albanis, S. L. Friedman

Research output: Contribution to journalArticlepeer-review

183 Scopus citations

Abstract

There has been great progress made in our understanding of the cellular mechanism of hepatic fibrosis. The recognition that the hepatic stellate cell, (formerly know as lipocyte, Ito, or fat-storing cell), played a central role in the fibrotic response was key to our understanding. Stellate cells undergo a process known as activation, in response to any insult. Activation is a broad phenotypic response, characterized by distinct, function changes in proliferation, fibrogenesis, contractility, cytokine secretion, and matrix degradation. Insights gained into the molecular regulations of stellate cell activation may lead to new antifibrotic therapies, which may reduce morbidity and mortality in patients with chronic liver injury.

Original languageEnglish
Pages (from-to)315-334
Number of pages20
JournalClinics in Liver Disease
Volume5
Issue number2
DOIs
StatePublished - 2001
Externally publishedYes

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