Hepatic fibrogenesis

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Hepatic fibrogenesis is a complex process that is driven by activated hepatic stellate cells as part of the liver's normal wound healing response. These cells drive the process through matrix production, cytokine secretion, and immune and other cell-cell interactions. Ultimately, fibrosis accumulates when matrix production outpaces matrix degradation. This chapter explores the complex interplay of genetic, environmental, and social factors on the progression of fibrosis. Furthermore, it assesses the efficacy and limitations of non-invasive markers for fibrosis staging and highlights the pressing need for more accurate markers linked to clinically meaningful outcomes. This need is particularly urgent for the development of antifibrotic treatments, especially for conditions like metabolic dysfunction-associated steatohepatitis (MASH), to improve patient management and therapeutic success.

Original languageEnglish
Title of host publicationHepatology
Subtitle of host publicationan Evidence-Based Clinical Compendium: Volume 1-2
PublisherElsevier
Pages247-272
Number of pages26
Volume1-2
ISBN (Electronic)9780443300523
ISBN (Print)9780443300530
DOIs
StatePublished - 1 Jan 2024

Keywords

  • Antifibrotic therapies
  • Fibrogenesis
  • Hepatic stellate cells
  • Liver fibrosis
  • Non-invasive markers

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