Hepatic Encephalopathy Challenges, Burden, and Diagnostic and Therapeutic Approach

Beshoy Yanny, Adam Winters, Sandra Boutros, Sammy Saab

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Hepatic encephalopathy (HE) is an important cause of morbidity and mortality in patients with cirrhosis. The impact of HE on the health care system is similarly profound. The number of hospital admissions for HE has increased in the last 10-year period. HE is a huge burden to the patients, care givers, and the health care system. HE represents a “revolving door” with readmission, severely affects care givers, and has effects on cognition that can persists after liver transplant. This article reviews the current literature to discuss the challenges and diagnostic and therapeutic approaches to HE.

Original languageEnglish
Pages (from-to)607-623
Number of pages17
JournalClinics in Liver Disease
Issue number4
StatePublished - Nov 2019
Externally publishedYes


  • Hepatic encephalopathy
  • Liver cirrhosis
  • Portal hypertension
  • Refractory hepatic encephalopathy


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