@article{f501f1a702c94bfb8437beeca9610c2f,
title = "Hepatic cells derived from induced pluripotent stem cells of pigtail macaques support hepatitis C virus infection",
abstract = "The narrow species tropism of hepatitis C virus (HCV) limits animal studies. We found that pigtail macaque (Macaca nemestrina) hepatic cells derived from induced pluripotent stem cells support the entire HCV life cycle, although infection efficiency was limited by defects in the HCV cell entry process. This block was overcome by either increasing occludin expression, complementing the cells with human CD81, or infecting them with a strain of HCV with less restricted requirements for CD81. Using this system, we can modify viral and host cell genetics to make pigtail macaques a suitable, clinically relevant model for the study of HCV infection.",
keywords = "Animal Model, Hepatitis C Virus, Monkey, Replication",
author = "Marion Sourisseau and Orit Goldman and Wenqian He and Gori, {Jennifer L.} and Kiem, {Hans Peter} and Valerie Gouon-Evans and Evans, {Matthew J.}",
note = "Funding Information: Funding M.S. was supported by the Robin Chemers Neustein Postdoctoral Fellowship. H.-P.K. is a Markey Molecular Medicine investigator and the recipient of the Jose Carreras/E.D. Thomas Chair for Cancer Research as well as National Institutes of Health (NIH) grants R01 HL098489 and P51 RR00016 . V.G.-E. was supported by the Black Family Stem Cell Institute at the Icahn School of Medicine at Mount Sinai and NIH grant R01 DK087867 . M.J.E. was supported by NIH grants R01 DK095125, R00 AI077800, and R56 AI091792 ; an American Cancer Society Research Scholar Grant ( RSG-12-176-01-MPC ); and the Pew Charitable Funds. ",
year = "2013",
month = nov,
doi = "10.1053/j.gastro.2013.07.026",
language = "English",
volume = "145",
pages = "966--969.e7",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders",
number = "5",
}