Heparin-Induced Thrombocytopenia: A Comprehensive Clinical Review

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Heparin-induced thrombocytopenia is a profoundly dangerous, potentially lethal, immunologically mediated adverse drug reaction to unfractionated heparin or, less commonly, to low-molecular weight heparin. In this comprehensive review, the authors highlight heparin-induced thrombocytopenia's risk factors, clinical presentation, pathophysiology, diagnostic principles, and treatment. The authors place special emphasis on the management of patients requiring procedures using cardiopulmonary bypass or interventions in the catheterization laboratory. Clinical vigilance of this disease process is important to ensure its recognition, diagnosis, and treatment. Misdiagnosis of the syndrome, as well as misunderstanding of the disease process, continues to contribute to its morbidity and mortality.

Original languageEnglish
Pages (from-to)2519-2532
Number of pages14
JournalJournal of the American College of Cardiology
Issue number21
StatePublished - 31 May 2016


  • anticoagulant agents
  • antithrombin agents
  • argatroban
  • bivalirudin
  • cardiopulmonary bypass
  • platelets


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