Heparin facilitates the extraction of tissue fibronectin

Bonnie Anderson Bray, Ines Mandl, Gerard M. Turino

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Extraction of fibronectin from two human tissues, lung parenchyma and placental villi, was facilitated by the incorporation of heparin into extraction media. The effect of heparin was additive to the effect of urea which is known to extract fibronectin. These experiments provide further evidence that fibronectin and glycosaminoglycans are associated in connective tissues and the use of heparin forms the basis for a simple method for extraction and quantitation of tissue fibronectin.

Original languageEnglish
Pages (from-to)793-795
Number of pages3
JournalScience
Volume214
Issue number4522
DOIs
StatePublished - 1981
Externally publishedYes

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