Heparin-based nanoparticles

Melissa M. Kemp, Robert J. Linhardt

Research output: Contribution to journalReview articlepeer-review

121 Scopus citations


The combination of nanoparticles and biological molecules is of intense interest because of the synergistic properties offered by such newly synthesized composites. Heparin (HP), conjugated to nanomaterials, has recently been investigated for its chemical and biological properties. HP has a number of biological activities that can be enhanced when composited with nanoparticles. In addition, HP improves the biocompatibility of nanoparticles improving their performance in various biological applications. A variety of recent research combines HP and nanomaterials for a myriad of applications. HP has been conjugated to the surface of the nanoparticles, such as magnetic and metallic nanoparticles, or biodegradable and nondegradable synthetic polymers. HP has also been incorporated into the nanoparticles. There are numerous possibilities for material composites and chemistries that incorporate HP. This opens the door for novel applications ranging from improving anticoagulant activity, for anticancer and antitumor therapy, to tissue engineering and biosensors. This review examines the different possibilities of HP-based nanoparticle composites and their medicinal or biological applications.

Original languageEnglish
Pages (from-to)77-87
Number of pages11
JournalWiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
Issue number1
StatePublished - 2010
Externally publishedYes


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