Henoch-Schoenlein purpura associated with Helicobacter pylori infection and duodenal ulcer

A 25 years old female presenting upper abdominal pain, retrosternal burning, joint pains and later developing palpable purpura over the lower limbs. Her upper gastrointestinal endoscopic studies indicated duodenal ulcer, antral gastritis and Helicobacter pylori infection. The findings of skin biopsy and immunofluorescence were consistent with Henoch-Schoenlein purpura. The eradication of H. pylori by pentaperazole, clarithromycin and amoxicillin subsided clinical manifestations. This case report and review of literature suggests that H. pylori infection may have a definitive etiological role in the causation of Henoch-Schoenlein purpura.