Recurrent pneumonia with cavitation leading to pneumatoceles, secondary fungal infections, and hemoptysis are major causes of mortality and morbidity in patients with hyper-IgE syndrome. Prevention and aggressive treatment of pneumonia in these patients are essential to prevent further lung damage, but treatment may be delayed because the classic signs/symptoms of infection such as fever, chills, or rigors may be lacking. Early imaging to identify infection is essential for diagnosis and treatment. The mainstay of therapy is continuous, full-dose daily trimethoprim-sulfamethoxazole and commonly fungal coverage. Because hyper-IgE syndrome is a progressive disease, patients' condition may worsen despite compliance with prophylactic therapy.

Original languageEnglish
Pages (from-to)1054-1058
Number of pages5
JournalJournal of Allergy and Clinical Immunology: In Practice
Issue number6
StatePublished - 1 Nov 2016


  • Aspergilloma
  • Eczema
  • Immunodeficiency
  • STAT3
  • hyper-IgE syndrome


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