Hemopoietic stem cell transplants for multiple myeloma

S. Jagannath, D. H. Vesole, G. Tricot, J. Crowley, S. E. Salmon, B. Barlogie

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Recently, high-dose therapy has been evaluated in patients with multiple myeloma, mainly with autologous transplant support. As a result of rapid hemopoietic engraftment with peripheral blood stem cells collected after chemotherapy and/or hemopoietic growth factor priming, procedure-related mortality has dropped to below 5%. When applied within 12 months from initial therapy, autologous transplants effect complete remissions in up to 50% of patients, with median event-free and overall survival durations on the order of 2.5 and 4 to 5 years, respectively. Complete response rates with allogeneic transplantation range from 30% to 50%, and procedure-related mortality is approximately 40%. Although the median durations of event-free and overall survival are shorter with allogeneic transplants, approximately 35% to 40% of patients survive with minimal disease for at least 5 to 6 years. Direct comparison of standard therapy and autologous transplants have just begun.

Original languageEnglish
Pages (from-to)89-100+103
JournalOncology
Volume8
Issue number11
StatePublished - 1994
Externally publishedYes

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