TY - JOUR
T1 - Hemophagocytic syndrome occurring in an adult liver transplant recipient having Still's disease
AU - Satapathy, Sanjaya K.
AU - Isabel Fiel, M.
AU - Del Rio Martin, Juan
AU - Aloman, Costica
AU - Schiano, Thomas D.
PY - 2011/3
Y1 - 2011/3
N2 - Hemophagocytic syndrome is a potentially fatal complication that rarely occurs after liver transplantation. We present a 25-year-old man with a history of Still's disease who presented with fever, arthralgia, and elevated serum ferritin levels 6 months after undergoing liver transplantation for fulminant hepatic failure due to autoimmune hepatitis potentially triggered by infliximab therapy. Liver biopsy demonstrated features consistent with hemophagocytic syndrome. The patient was successfully treated with a course of high dose steroids and had complete resolution of his symptoms and normalization of liver chemistry test abnormalities. Patients with Still's disease may rarely complicate with fulminant hepatic failure with infliximab therapy. Hemophagocytic syndrome a rare potentially life threatening condition may occur in such patients following liver transplantation.
AB - Hemophagocytic syndrome is a potentially fatal complication that rarely occurs after liver transplantation. We present a 25-year-old man with a history of Still's disease who presented with fever, arthralgia, and elevated serum ferritin levels 6 months after undergoing liver transplantation for fulminant hepatic failure due to autoimmune hepatitis potentially triggered by infliximab therapy. Liver biopsy demonstrated features consistent with hemophagocytic syndrome. The patient was successfully treated with a course of high dose steroids and had complete resolution of his symptoms and normalization of liver chemistry test abnormalities. Patients with Still's disease may rarely complicate with fulminant hepatic failure with infliximab therapy. Hemophagocytic syndrome a rare potentially life threatening condition may occur in such patients following liver transplantation.
KW - Liver transplantation
KW - Macrophage activation syndrome
KW - Rheumatoid arthritis
UR - http://www.scopus.com/inward/record.url?scp=79952618759&partnerID=8YFLogxK
U2 - 10.1007/s12072-010-9218-y
DO - 10.1007/s12072-010-9218-y
M3 - Article
AN - SCOPUS:79952618759
SN - 1936-0533
VL - 5
SP - 597
EP - 602
JO - Hepatology International
JF - Hepatology International
IS - 1
ER -