TY - JOUR
T1 - Hemolytik
T2 - A database of experimentally determined hemolytic and non-hemolytic peptides
AU - Gautam, Ankur
AU - Chaudhary, Kumardeep
AU - Singh, Sandeep
AU - Joshi, Anshika
AU - Anand, Priya
AU - Tuknait, Abhishek
AU - Mathur, Deepika
AU - Varshney, Grish C.
AU - Raghava, Gajendra P.S.
N1 - Funding Information:
Council of Scientific and Industrial Research Projects: Open Source Drug Discovery and GENESIS BSC0121. Department of Biotechnology (Project: BTISNET), Government of India. Funding for open access charge: Projects: Open Source Drug Discovery and GENESIS BSC0121.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Hemolytik (http://crdd.osdd.net/raghava/hemolytik/) is a manually curated database of experimentally determined hemolytic and non-hemolytic peptides. Data were compiled from a large number of published research articles and various databases like Antimicrobial Peptide Database, Collection of Anti-microbial Peptides, Dragon Antimicrobial Peptide Database and Swiss-Prot. The current release of Hemolytik database contains ∼3000 entries that include ∼2000 unique peptides whose hemolytic activities were evaluated on erythrocytes isolated from as many as 17 different sources. Each entry in Hemolytik provides comprehensive information about a peptide, like its name, sequence, origin, reported function, property such as chirality, types (linear and cyclic), end modifications as well as details pertaining to its hemolytic activity. In addition, tertiary structure of each peptide has been predicted, and secondary structure states have been assigned. To facilitate the scientific community, a user-friendly interface has been developed with various tools for data searching and analysis. We hope, Hemolytik will be useful for researchers working in the field of designing therapeutic peptides.
AB - Hemolytik (http://crdd.osdd.net/raghava/hemolytik/) is a manually curated database of experimentally determined hemolytic and non-hemolytic peptides. Data were compiled from a large number of published research articles and various databases like Antimicrobial Peptide Database, Collection of Anti-microbial Peptides, Dragon Antimicrobial Peptide Database and Swiss-Prot. The current release of Hemolytik database contains ∼3000 entries that include ∼2000 unique peptides whose hemolytic activities were evaluated on erythrocytes isolated from as many as 17 different sources. Each entry in Hemolytik provides comprehensive information about a peptide, like its name, sequence, origin, reported function, property such as chirality, types (linear and cyclic), end modifications as well as details pertaining to its hemolytic activity. In addition, tertiary structure of each peptide has been predicted, and secondary structure states have been assigned. To facilitate the scientific community, a user-friendly interface has been developed with various tools for data searching and analysis. We hope, Hemolytik will be useful for researchers working in the field of designing therapeutic peptides.
UR - http://www.scopus.com/inward/record.url?scp=84891778045&partnerID=8YFLogxK
U2 - 10.1093/nar/gkt1008
DO - 10.1093/nar/gkt1008
M3 - Article
C2 - 24174543
AN - SCOPUS:84891778045
SN - 0305-1048
VL - 42
SP - D444-D449
JO - Nucleic Acids Research
JF - Nucleic Acids Research
IS - D1
ER -