TY - JOUR
T1 - Hemoglobin-based oxygen carrier (HBOC-201) and escalating doses of recombinant factor VIIa (rFVIIa) as a novel pre-hospital resuscitation fluid in a swine model of severe uncontrolled hemorrhage
AU - Scultetus, Anke
AU - Arnaud, Francoise
AU - Kaplan, Lewis
AU - Shander, Aryeh
AU - Philbin, Nora
AU - Rice, Jennifer
AU - McCarron, Richard
AU - Freilich, Daniel
N1 - Funding Information:
The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, nor the U.S. Government. This work was supported by BUMED Core Capability Funding Work Unit Number 602236N.M04426.B26.A0241. The authors thank Noemy Carballo, Benjamin Esperat, Mike Hammett, and Daniel Fasipe from the Naval Medical Research Center for their technical assistance, Gerald McGwin, PhD, University of Alabama, for statistical analysis, Stephen Ahlers, PhD, Naval Medical Research Center, and David Burris, MD, FACS, Uniformed Services University of the Health Sciences, for valuable scientific critique. Address correspondence to: Anke H. Scultetus, MD, 503 Robert Grant Avenue, NeuroTrauma Department, Naval Medical Research Center, Silver Spring, MD 20910, USA. E-mail: [email protected]
PY - 2011/4
Y1 - 2011/4
N2 - Exsanguinating hemorrhage and unavailability of blood are major problems in pre-hospital trauma care. We investigated if combining rFVIIa with HBOC-201 reduces blood loss and improves physiologic parameters compared to HBOC alone. Swine underwent liver injury and were resuscitated with HBOC-201 alone or HBOC+90, 180 or 360 μg/kg rFVIIa before hospital arrival at 240 min; animals survived to 72 hours. Blood loss was reduced; MAP, CI, transcutaneous oxygen saturation, and 72-hour survival improved in the 90 and 180 μg/kg rFVIIa groups. Lactate was cleared faster in the HBOC+rFVIIa 90 μg/kg group. Verification in a large, well-powered study is indicated.
AB - Exsanguinating hemorrhage and unavailability of blood are major problems in pre-hospital trauma care. We investigated if combining rFVIIa with HBOC-201 reduces blood loss and improves physiologic parameters compared to HBOC alone. Swine underwent liver injury and were resuscitated with HBOC-201 alone or HBOC+90, 180 or 360 μg/kg rFVIIa before hospital arrival at 240 min; animals survived to 72 hours. Blood loss was reduced; MAP, CI, transcutaneous oxygen saturation, and 72-hour survival improved in the 90 and 180 μg/kg rFVIIa groups. Lactate was cleared faster in the HBOC+rFVIIa 90 μg/kg group. Verification in a large, well-powered study is indicated.
KW - HBOC-201
KW - hemorrhage
KW - pre-hospital trauma care
KW - rFVIIa
KW - resuscitation
UR - https://www.scopus.com/pages/publications/79952416265
U2 - 10.3109/10731199.2010.501755
DO - 10.3109/10731199.2010.501755
M3 - Article
C2 - 20645681
AN - SCOPUS:79952416265
SN - 1073-1199
VL - 39
SP - 59
EP - 68
JO - Artificial Cells, Nanomedicine and Biotechnology
JF - Artificial Cells, Nanomedicine and Biotechnology
IS - 2
ER -