TY - GEN
T1 - Hematopoietic stem cell trafficking
T2 - Regulated adhesion and attraction to bone marrow microenvironment
AU - Méndez-Ferrer, Simón
AU - Frenette, Paul S.
PY - 2007/11
Y1 - 2007/11
N2 - Hematopoiesis takes place preferentially within bone cavities, suggesting that bone-derived factors contribute to blood formation. Hematopoietic stem and progenitor cells (HSPCs) can be mobilized from the bone marrow parenchyma to the circulation by various agonists whose common downstream action leads to alteration in the expression or function of the chemokine CXCL12 and adhesion molecules mediating migration. Granulocyte colony-stimulating factor (G-CSF), the most prevalent drug used to mobilize HSPCs, dramatically suppresses osteoblast function. Recent studies suggest that G-CSF-mediated suppression requires signals from the sympathetic nervous system (SNS). This review summarizes emerging concepts thought to contribute to stem cell migration.
AB - Hematopoiesis takes place preferentially within bone cavities, suggesting that bone-derived factors contribute to blood formation. Hematopoietic stem and progenitor cells (HSPCs) can be mobilized from the bone marrow parenchyma to the circulation by various agonists whose common downstream action leads to alteration in the expression or function of the chemokine CXCL12 and adhesion molecules mediating migration. Granulocyte colony-stimulating factor (G-CSF), the most prevalent drug used to mobilize HSPCs, dramatically suppresses osteoblast function. Recent studies suggest that G-CSF-mediated suppression requires signals from the sympathetic nervous system (SNS). This review summarizes emerging concepts thought to contribute to stem cell migration.
KW - Adhesion
KW - Hematopoietic stem and progenitor cells
KW - Homing
KW - Mobilization
KW - Stem cell niche
KW - Sympathetic nervous system
UR - http://www.scopus.com/inward/record.url?scp=37249055951&partnerID=8YFLogxK
U2 - 10.1196/annals.1402.086
DO - 10.1196/annals.1402.086
M3 - Conference contribution
C2 - 18083941
AN - SCOPUS:37249055951
SN - 9781573316842
T3 - Annals of the New York Academy of Sciences
SP - 392
EP - 413
BT - Skeletal Biology and Medicine, Part A
PB - Blackwell Publishing Inc.
ER -