Hemagglutinin stalk immunity reduces influenza virus replication and transmission in ferrets

Raffael Nachbagauer; Matthew S. Miller; Rong Hai; Alex B. Ryder; John K. Rose; Peter Palese; Adolfo García-Sastre; Florian Krammer; Randy A. Albrecht

doi:10.1128/JVI.02481-15

Hemagglutinin stalk immunity reduces influenza virus replication and transmission in ferrets

Raffael Nachbagauer
, Matthew S. Miller
, Rong Hai
, Alex B. Ryder
, John K. Rose
, Peter Palese
, Adolfo García-Sastre
, Florian Krammer
, Randy A. Albrecht

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

We assessed whether influenza virus hemagglutinin stalk-based immunity protects ferrets against aerosol-transmitted H1N1 influenza virus infection. Immunization of ferrets by a universal influenza virus vaccine strategy based on viral vectors expressing chimeric hemagglutinin constructs induced stalk-specific antibody responses. Stalk-immunized ferrets were cohoused with H1N1-infected ferrets under conditions that permitted virus transmission. Hemagglutinin stalk-immunized ferrets had lower viral titers and delayed or no virus replication at all following natural exposure to influenza virus.

Original language	English
Pages (from-to)	3268-3273
Number of pages	6
Journal	Journal of Virology
Volume	90
Issue number	6
DOIs	https://doi.org/10.1128/JVI.02481-15
State	Published - 2016

Access to Document

10.1128/JVI.02481-15

Cite this

@article{3c240bf48e67446ba81fac40e714e458,

title = "Hemagglutinin stalk immunity reduces influenza virus replication and transmission in ferrets",

abstract = "We assessed whether influenza virus hemagglutinin stalk-based immunity protects ferrets against aerosol-transmitted H1N1 influenza virus infection. Immunization of ferrets by a universal influenza virus vaccine strategy based on viral vectors expressing chimeric hemagglutinin constructs induced stalk-specific antibody responses. Stalk-immunized ferrets were cohoused with H1N1-infected ferrets under conditions that permitted virus transmission. Hemagglutinin stalk-immunized ferrets had lower viral titers and delayed or no virus replication at all following natural exposure to influenza virus.",

author = "Raffael Nachbagauer and Miller, \{Matthew S.\} and Rong Hai and Ryder, \{Alex B.\} and Rose, \{John K.\} and Peter Palese and Adolfo Garc{\'i}a-Sastre and Florian Krammer and Albrecht, \{Randy A.\}",

note = "Publisher Copyright: {\textcopyright} 2016, American Society for Microbiology.",

year = "2016",

doi = "10.1128/JVI.02481-15",

language = "English",

volume = "90",

pages = "3268--3273",

journal = "Journal of Virology",

issn = "0022-538X",

publisher = "American Society for Microbiology",

number = "6",

}

TY - JOUR

T1 - Hemagglutinin stalk immunity reduces influenza virus replication and transmission in ferrets

AU - Nachbagauer, Raffael

AU - Miller, Matthew S.

AU - Hai, Rong

AU - Ryder, Alex B.

AU - Rose, John K.

AU - Palese, Peter

AU - García-Sastre, Adolfo

AU - Krammer, Florian

AU - Albrecht, Randy A.

PY - 2016

Y1 - 2016

N2 - We assessed whether influenza virus hemagglutinin stalk-based immunity protects ferrets against aerosol-transmitted H1N1 influenza virus infection. Immunization of ferrets by a universal influenza virus vaccine strategy based on viral vectors expressing chimeric hemagglutinin constructs induced stalk-specific antibody responses. Stalk-immunized ferrets were cohoused with H1N1-infected ferrets under conditions that permitted virus transmission. Hemagglutinin stalk-immunized ferrets had lower viral titers and delayed or no virus replication at all following natural exposure to influenza virus.

AB - We assessed whether influenza virus hemagglutinin stalk-based immunity protects ferrets against aerosol-transmitted H1N1 influenza virus infection. Immunization of ferrets by a universal influenza virus vaccine strategy based on viral vectors expressing chimeric hemagglutinin constructs induced stalk-specific antibody responses. Stalk-immunized ferrets were cohoused with H1N1-infected ferrets under conditions that permitted virus transmission. Hemagglutinin stalk-immunized ferrets had lower viral titers and delayed or no virus replication at all following natural exposure to influenza virus.

UR - https://www.scopus.com/pages/publications/84961114525

U2 - 10.1128/JVI.02481-15

DO - 10.1128/JVI.02481-15

M3 - Article

C2 - 26719251

AN - SCOPUS:84961114525

SN - 0022-538X

VL - 90

SP - 3268

EP - 3273

JO - Journal of Virology

JF - Journal of Virology

IS - 6

ER -

Hemagglutinin stalk immunity reduces influenza virus replication and transmission in ferrets

Abstract

Access to Document

Fingerprint

Cite this