Hemagglutinin stalk immunity reduces influenza virus replication and transmission in ferrets

Raffael Nachbagauer, Matthew S. Miller, Rong Hai, Alex B. Ryder, John K. Rose, Peter Palese, Adolfo García-Sastre, Florian Krammer, Randy A. Albrecht

Research output: Contribution to journalArticlepeer-review

72 Scopus citations

Abstract

We assessed whether influenza virus hemagglutinin stalk-based immunity protects ferrets against aerosol-transmitted H1N1 influenza virus infection. Immunization of ferrets by a universal influenza virus vaccine strategy based on viral vectors expressing chimeric hemagglutinin constructs induced stalk-specific antibody responses. Stalk-immunized ferrets were cohoused with H1N1-infected ferrets under conditions that permitted virus transmission. Hemagglutinin stalk-immunized ferrets had lower viral titers and delayed or no virus replication at all following natural exposure to influenza virus.

Original languageEnglish
Pages (from-to)3268-3273
Number of pages6
JournalJournal of Virology
Volume90
Issue number6
DOIs
StatePublished - 2016

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