@article{ffe0d9a631eb451f8548eeb1a52f0835,
title = "Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients",
abstract = "Zhou et al. use metatranscriptomic sequencing to profile immune signatures in the bronchoalveolar lavage fluid of COVID-19 patients. COVID-19 patients exhibit robust innate immune responses with notable hypercytokinemia and increased expression of IFN-stimulated genes. This analysis provides timely information for understanding SARS-CoV-2-host interactions and COVID-19 pathogenesis.",
keywords = "Bronchoalveolar lavage fluid, COVID-19, Chemokines, Coronavirus, Hypercytokinemia, Innate immune response, Interferon response, Interferon-stimulated genes, Metatranscriptomic sequencing, SARS-CoV-2",
author = "Zhuo Zhou and Lili Ren and Li Zhang and Jiaxin Zhong and Yan Xiao and Zhilong Jia and Li Guo and Jing Yang and Chun Wang and Shuai Jiang and Donghong Yang and Guoliang Zhang and Hongru Li and Fuhui Chen and Yu Xu and Mingwei Chen and Zhancheng Gao and Jian Yang and Jie Dong and Bo Liu and Xiannian Zhang and Weidong Wang and Kunlun He and Qi Jin and Mingkun Li and Jianwei Wang",
note = "Funding Information: We thank Dr. Xue Yongbiao (China National Center for Bioinformation), Dr. Wang Jianbin (Tsinghua University, Beijing, China), and Dr. Yanyi Huang (Peking University) for technical assistance and helpful discussions. This work was supported by grants from the National Major Science & Technology Project for Control and Prevention of Major Infectious Diseases in China (2017ZX10204401, 2018ZX10301401, 2017ZX10103004, 2018ZX10305409), the Innovation Fund for Medical Sciences (2016-I2M-1-014), the National Natural Science Foundation of China (31670169, 31470267, 31701155), the National Key Research and Development Program of China (2017YFC0908403, 2020YFA0707600), the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (2019PT310029), the Strategic Priority CAS Project (XDB38000000), Chinese Academy of Sciences, and the Beijing Advanced Innovation Center for Genomics (ICG). Conceptualization, J.W. M.L. L.R. and Q.J.; Lab work, L.R. Y.X. L.G. and J.D.; Data, Q.C. J.Z. M.L. Jian Yang, and B.L.; High-throughput sequencing, X.Z.; Transcriptomic analysis, Z.Z. L.Z. J.Z. Z.J. Jing Yang, C.W. S.J. W.W. and K.H.; Clinical sample management, L.R. Y.X. D.Y. G.Z. H.L. F.C. Y.X. M.C. and Z.G.; Writing - Original Draft, Z.Z. L.Z. J.Z. M.L. and J.W.; Writing - Review & Editing, J.W. M.L. Z.Z. L.Z. and L.R. The authors declare no competing interests. Funding Information: We thank Dr. Xue Yongbiao (China National Center for Bioinformation), Dr. Wang Jianbin (Tsinghua University, Beijing, China), and Dr. Yanyi Huang (Peking University) for technical assistance and helpful discussions. This work was supported by grants from the National Major Science & Technology Project for Control and Prevention of Major Infectious Diseases in China ( 2017ZX10204401 , 2018ZX10301401 , 2017ZX10103004 , 2018ZX10305409 ), the Innovation Fund for Medical Sciences ( 2016-I2M-1-014 ), the National Natural Science Foundation of China ( 31670169 , 31470267 , 31701155 ), the National Key Research and Development Program of China ( 2017YFC0908403, 2020YFA0707600 ), the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences ( 2019PT310029 ), the Strategic Priority CAS Project (XDB38000000), Chinese Academy of Sciences, and the Beijing Advanced Innovation Center for Genomics (ICG). Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = jun,
day = "10",
doi = "10.1016/j.chom.2020.04.017",
language = "English",
volume = "27",
pages = "883--890.e2",
journal = "Cell Host and Microbe",
issn = "1931-3128",
publisher = "Cell Press",
number = "6",
}