Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients

Zhuo Zhou, Lili Ren, Li Zhang, Jiaxin Zhong, Yan Xiao, Zhilong Jia, Li Guo, Jing Yang, Chun Wang, Shuai Jiang, Donghong Yang, Guoliang Zhang, Hongru Li, Fuhui Chen, Yu Xu, Mingwei Chen, Zhancheng Gao, Jian Yang, Jie Dong, Bo LiuXiannian Zhang, Weidong Wang, Kunlun He, Qi Jin, Mingkun Li, Jianwei Wang

Research output: Contribution to journalArticlepeer-review

535 Scopus citations

Abstract

Zhou et al. use metatranscriptomic sequencing to profile immune signatures in the bronchoalveolar lavage fluid of COVID-19 patients. COVID-19 patients exhibit robust innate immune responses with notable hypercytokinemia and increased expression of IFN-stimulated genes. This analysis provides timely information for understanding SARS-CoV-2-host interactions and COVID-19 pathogenesis.

Original languageEnglish
Pages (from-to)883-890.e2
JournalCell Host and Microbe
Volume27
Issue number6
DOIs
StatePublished - 10 Jun 2020
Externally publishedYes

Keywords

  • Bronchoalveolar lavage fluid
  • COVID-19
  • Chemokines
  • Coronavirus
  • Hypercytokinemia
  • Innate immune response
  • Interferon response
  • Interferon-stimulated genes
  • Metatranscriptomic sequencing
  • SARS-CoV-2

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