TY - JOUR
T1 - Heavy alcohol consumption and risk of atrial fibrillation
T2 - The circulatory risk in communities study (circs)
AU - Sano, Fumihiko
AU - Ohira, Tetsuya
AU - Kitamura, Akihiko
AU - Imano, Hironori
AU - Cui, Renzhe
AU - Kiyama, Masahiko
AU - Okada, Takeo
AU - Yamagishi, Kazumasa
AU - Sankai, Tomoko
AU - Tanigawa, Takeshi
AU - Kario, Kazuomi
AU - Iso, Hiroyasu
PY - 2014
Y1 - 2014
N2 - Background: Evidence regarding the relationship between different levels of alcohol consumption and the risk of atrial fibrillation (AF) is currently limited in Asian populations. Methods and Results: Between 1991 and 1995, a total of 8,602 Japanese men and women aged 30-80 years took part in the first examination of the Circulatory Risk in Communities Study (CIRCS), a population-based cohort study in Japanese communities. An interviewer obtained detailed information on weekly alcohol intake. During the follow-up period, the incidence of AF was ascertained from annual ECG records, the subject's medical history of AF, and cardiovascular disease surveillance. The hazard ratios (HRs) of incident AF and the 95% confidence intervals (CIs) relative to the never-drinking group were calculated with adjustment for potential confounding factors by using the Cox proportional hazard model. During a median follow-up period of 6.4 years, 296 incidents of AF occurred. A higher incidence of AF was observed among participants with an ethanol intake >69 g/day, compared with never-drinkers. Compared with the never-drinkers, the multivariable-adjusted HRs (CIs) of past, light (<23 g/day), light-moderate (23-46 g/day), moderate (46-69 g/day), and heavy (>69 g/day) drinkers were 1.30 (0.68-2.49), 0.89 (0.60-1.32), 1.19 (0.73-1.95), 1.36 (0.79-2.35), and 2.90 (1.61-5.23), respectively. Conclusions: Heavy alcohol consumption is associated with a higher risk of AF.
AB - Background: Evidence regarding the relationship between different levels of alcohol consumption and the risk of atrial fibrillation (AF) is currently limited in Asian populations. Methods and Results: Between 1991 and 1995, a total of 8,602 Japanese men and women aged 30-80 years took part in the first examination of the Circulatory Risk in Communities Study (CIRCS), a population-based cohort study in Japanese communities. An interviewer obtained detailed information on weekly alcohol intake. During the follow-up period, the incidence of AF was ascertained from annual ECG records, the subject's medical history of AF, and cardiovascular disease surveillance. The hazard ratios (HRs) of incident AF and the 95% confidence intervals (CIs) relative to the never-drinking group were calculated with adjustment for potential confounding factors by using the Cox proportional hazard model. During a median follow-up period of 6.4 years, 296 incidents of AF occurred. A higher incidence of AF was observed among participants with an ethanol intake >69 g/day, compared with never-drinkers. Compared with the never-drinkers, the multivariable-adjusted HRs (CIs) of past, light (<23 g/day), light-moderate (23-46 g/day), moderate (46-69 g/day), and heavy (>69 g/day) drinkers were 1.30 (0.68-2.49), 0.89 (0.60-1.32), 1.19 (0.73-1.95), 1.36 (0.79-2.35), and 2.90 (1.61-5.23), respectively. Conclusions: Heavy alcohol consumption is associated with a higher risk of AF.
KW - Alcohol
KW - Atrial fibrillation
KW - Epidemiology
KW - Risk factors
UR - https://www.scopus.com/pages/publications/84897857136
U2 - 10.1253/circj.cj-13-1387
DO - 10.1253/circj.cj-13-1387
M3 - Article
C2 - 24553265
AN - SCOPUS:84897857136
SN - 1346-9843
VL - 78
SP - 955
EP - 961
JO - Circulation Journal
JF - Circulation Journal
IS - 4
ER -