Heart failure: Emerging concepts in excitation-contraction coupling and β-adrenoceptor coupling

Clive J. Lewis, Federica Del Monte, Sian E. Harding, Roger J. Hajjar

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

The process that begins contraction in the heart is known as excitation - contraction (E - C) coupling because it couples electrical signals on the membrane of the cardiac cell to activation of the myofilament and cross-bridge cycling. The cardiac action potential is produced by the coordinated interaction of many ion channels, which transduce physiological signals within and between cardiomyocytes. These cardiomyocytes are further regulated by a number of receptors that control the strength of the contraction on a beat-to-beat basis and their morphology in a chronic fashion. In heart failure, a number of steps in E - C coupling become abnormal. In this chapter, we will examine the role of these abnormalities in the development of heart failure.

Original languageEnglish
Title of host publicationPrinciples of Molecular Medicine
PublisherHumana Press
Pages105-115
Number of pages11
ISBN (Print)9781588292025
DOIs
StatePublished - 2006
Externally publishedYes

Keywords

  • G proteins
  • L-type calcium channel
  • calcium
  • contractility
  • excitation contraction coupling
  • myofilaments
  • phospholamban
  • sarcoplasmic reticulum
  • sodium calcium exchanger
  • β-receptor kinase
  • β-receptors

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