Healthcare utilization and statin re-initiation among medicare beneficiaries with a history of myocardial infarction

John N. Booth, Lisandro D. Colantonio, Robert S. Rosenson, Monika M. Safford, Ligong Chen, Meredith L. Kilgore, Todd M. Brown, Benjamin Taylor, Ricardo Dent, Keri L. Monda, Paul Muntner, Emily B. Levitan

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Background--Contact with the healthcare system represents an opportunity for individuals who discontinue statins to re-initiate treatment. To help identify opportunities for healthcare providers to emphasize the risk-lowering benefits accrued through restarting statins, we determined the types of healthcare utilization associated with statin re-initiation among patients with history of a myocardial infarction. Methods and Results--Medicare beneficiaries with a statin pharmacy fill claim within 30 days of hospital discharge for a myocardial infarction in 2007 to 2012 (n=158 795) were followed for 182 days postdischarge to identify treatment discontinuation, defined as 60 continuous days without statins (n=24 461). Re-initiation was defined as a statin fill within 365 days of the discontinuation date (n=13 136). Using a case-crossover study design and each beneficiary as their own control, healthcare utilization during 0 to 14 days before statin re-initiation (case period) was compared with healthcare utilization 30 to 44 days before statin re-initiation (control period). The mean age of beneficiaries was 75.4 years; 52.8% were women and 81.9% were white. For routine healthcare utilization, the odds ratio (95% confidence interval) for statin re-initiation associated with lipid panel testing was 2.65 (1.93-3.65), outpatient primary care was 1.31 (1.23-1.40), and outpatient cardiologist care was 1.38 (1.28-1.50). For acute healthcare utilization, the odds ratio (95% confidence interval) for statin re-initiation associated with emergency department visits was 1.77 (1.31-2.40), coronary heart disease (CHD) hospitalizations was 3.16 (2.41-4.14) and non- coronary heart disease hospitalizations was 1.73 (1.49-2.01). Conclusions--The weaker association of routine versus acute healthcare utilization with statin re-initiation suggests missed opportunities to reinforce the importance of statin therapy for secondary prevention.

Original languageEnglish
Article numbere008462
JournalJournal of the American Heart Association
Volume7
Issue number10
DOIs
StatePublished - 15 May 2018

Keywords

  • Case-crossover
  • Discontinuation
  • Re-initiation
  • Statin
  • Statin discontinuation
  • Statin re-initiation

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