Harnessing the immune system to treat cancer

Research output: Contribution to journalReview articlepeer-review

101 Scopus citations

Abstract

A major challenge for the immune system is to recognize and eliminate cells undergoing carcinogenesis. Immune defense against tumors is complex. It can be mediated early by the innate immune system (i.e., phagocytes, NK cells, NKT cells, cytokines, and complement proteins) and later by the adaptive immune system (i.e., B cells and T cells). The eight articles in this Review series on tumor immunology discuss the mechanisms underlying immune surveillance of tumors, the regulation of carcinogenesis by immune inflammatory mediators, current approaches to controlling tumor growth through immunotherapy, and novel targets of immunotherapy.

Original languageEnglish
Pages (from-to)1130-1136
Number of pages7
JournalJournal of Clinical Investigation
Volume117
Issue number5
DOIs
StatePublished - 1 May 2007
Externally publishedYes

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