Harnessing the Co-vulnerabilities of Amino Acid-Restricted Cancers

Gaurav Pathria, Ze'ev A. Ronai

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

Amino acid restriction is a promising strategy for cancer treatment; however, adaptive signaling and metabolic reprogramming confer resistance to the approach. In this Perspective, Pathria and Ronai discuss how the identification and co-targeting of signaling pathways underlying the resistance promise to offer durable therapeutic responses to amino acid restriction.

Original languageEnglish
Pages (from-to)9-20
Number of pages12
JournalCell Metabolism
Volume33
Issue number1
DOIs
StatePublished - 5 Jan 2021
Externally publishedYes

Keywords

  • ATF4
  • MAPK
  • NRF2
  • adaptation
  • amino acids
  • c-MYC
  • cancer
  • mTORC1
  • metabolism
  • resistance

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