Harnessing the Co-vulnerabilities of Amino Acid-Restricted Cancers

Gaurav Pathria; Ze'ev A. Ronai

doi:10.1016/j.cmet.2020.12.009

Harnessing the Co-vulnerabilities of Amino Acid-Restricted Cancers

Gaurav Pathria, Ze'ev A. Ronai

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

Amino acid restriction is a promising strategy for cancer treatment; however, adaptive signaling and metabolic reprogramming confer resistance to the approach. In this Perspective, Pathria and Ronai discuss how the identification and co-targeting of signaling pathways underlying the resistance promise to offer durable therapeutic responses to amino acid restriction.

Original language	English
Pages (from-to)	9-20
Number of pages	12
Journal	Cell Metabolism
Volume	33
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2020.12.009
State	Published - 5 Jan 2021
Externally published	Yes

Keywords

ATF4
MAPK
NRF2
adaptation
amino acids
c-MYC
cancer
mTORC1
metabolism
resistance

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10.1016/j.cmet.2020.12.009

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title = "Harnessing the Co-vulnerabilities of Amino Acid-Restricted Cancers",

abstract = "Amino acid restriction is a promising strategy for cancer treatment; however, adaptive signaling and metabolic reprogramming confer resistance to the approach. In this Perspective, Pathria and Ronai discuss how the identification and co-targeting of signaling pathways underlying the resistance promise to offer durable therapeutic responses to amino acid restriction.",

keywords = "ATF4, MAPK, NRF2, adaptation, amino acids, c-MYC, cancer, mTORC1, metabolism, resistance",

author = "Gaurav Pathria and Ronai, {Ze'ev A.}",

note = "Funding Information: We thank Daniela Senft for comments and figure preparation. Support by NCI grants R35CA197465 and R01CA202021 and DOD grant CA1810216 to Z.A.R. is gratefully acknowledged. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

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AU - Pathria, Gaurav

AU - Ronai, Ze'ev A.

N1 - Funding Information: We thank Daniela Senft for comments and figure preparation. Support by NCI grants R35CA197465 and R01CA202021 and DOD grant CA1810216 to Z.A.R. is gratefully acknowledged. Publisher Copyright: © 2020 Elsevier Inc.

PY - 2021/1/5

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N2 - Amino acid restriction is a promising strategy for cancer treatment; however, adaptive signaling and metabolic reprogramming confer resistance to the approach. In this Perspective, Pathria and Ronai discuss how the identification and co-targeting of signaling pathways underlying the resistance promise to offer durable therapeutic responses to amino acid restriction.

AB - Amino acid restriction is a promising strategy for cancer treatment; however, adaptive signaling and metabolic reprogramming confer resistance to the approach. In this Perspective, Pathria and Ronai discuss how the identification and co-targeting of signaling pathways underlying the resistance promise to offer durable therapeutic responses to amino acid restriction.

KW - ATF4

KW - MAPK

KW - NRF2

KW - adaptation

KW - amino acids

KW - c-MYC

KW - cancer

KW - mTORC1

KW - metabolism

KW - resistance

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U2 - 10.1016/j.cmet.2020.12.009

DO - 10.1016/j.cmet.2020.12.009

M3 - Review article

C2 - 33406406

AN - SCOPUS:85098622453

SN - 1550-4131

VL - 33

SP - 9

EP - 20

JO - Cell Metabolism

JF - Cell Metabolism

IS - 1

ER -

Harnessing the Co-vulnerabilities of Amino Acid-Restricted Cancers

Abstract

Keywords

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