@article{0725cb58f6404288b86298360c4474ff,
title = "Harnessing Genetic Complexity to Enhance Translatability of Alzheimer's Disease Mouse Models: A Path toward Precision Medicine",
abstract = "Neuner et al. describe the generation and validation of the AD-BXDs, the first reproducible set of AD mouse models incorporating genetic diversity. These models recapitulate aspects of human AD and provide a new resource to identify genes and pathways associated with risk and resilience to AD.",
keywords = "5XFAD, Alzheimer's, BXD, amyloid, genetic diversity, genetic risk score, mouse models, resilience, susceptibility, translational",
author = "Neuner, {Sarah M.} and Heuer, {Sarah E.} and Huentelman, {Matthew J.} and O'Connell, {Kristen M.S.} and Kaczorowski, {Catherine C.}",
note = "Funding Information: This study is part of the National Institute on Aging Resilience-AD program and is supported through the NIA grant award R01AG057914 to C.C.K. This work was also supported by the BrightFocus Foundation ( A2016397S to C.C.K.), the National Institute on Aging ( R01AG054180 to C.C.K.; F31AG050357 to S.M.N.; R01AG059778 to K.M.S.O. and C.C.K.), and the National Institute of Diabetes and Digestive and Kidney Diseases ( R01DK102918 to K.M.S.O.). Additional support was provided by the Evnin family , the University of Tennessee Health Science Center Neuroscience Institute , and the Translational Genomics Research Institute . The authors thank Dr. Lynda Wilmott and Thomas Shapaker for collection of behavioral data and Kwangbom Choi, Matthew de Both, Ryan Richholt, and Ashley Siniard for assistance with RNA sequencing. The authors would also like to thank Dr. Rob Williams for thoughtful input on the project design and Drs. Vivek Philip and Ji-Gang Zhang for assistance with data analysis. Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",
year = "2019",
month = feb,
day = "6",
doi = "10.1016/j.neuron.2018.11.040",
language = "English",
volume = "101",
pages = "399--411.e5",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "3",
}