Harnessing Genetic Complexity to Enhance Translatability of Alzheimer's Disease Mouse Models: A Path toward Precision Medicine

Sarah M. Neuner; Sarah E. Heuer; Matthew J. Huentelman; Kristen M.S. O'Connell; Catherine C. Kaczorowski

doi:10.1016/j.neuron.2018.11.040

Harnessing Genetic Complexity to Enhance Translatability of Alzheimer's Disease Mouse Models: A Path toward Precision Medicine

Sarah M. Neuner, Sarah E. Heuer, Matthew J. Huentelman, Kristen M.S. O'Connell, Catherine C. Kaczorowski

Research output: Contribution to journal › Article › peer-review

126 Scopus citations

Abstract

Neuner et al. describe the generation and validation of the AD-BXDs, the first reproducible set of AD mouse models incorporating genetic diversity. These models recapitulate aspects of human AD and provide a new resource to identify genes and pathways associated with risk and resilience to AD.

Original language	English
Pages (from-to)	399-411.e5
Journal	Neuron
Volume	101
Issue number	3
DOIs	https://doi.org/10.1016/j.neuron.2018.11.040
State	Published - 6 Feb 2019
Externally published	Yes

Keywords

5XFAD
Alzheimer's
BXD
amyloid
genetic diversity
genetic risk score
mouse models
resilience
susceptibility
translational

Access to Document

10.1016/j.neuron.2018.11.040

Cite this

@article{0725cb58f6404288b86298360c4474ff,

title = "Harnessing Genetic Complexity to Enhance Translatability of Alzheimer's Disease Mouse Models: A Path toward Precision Medicine",

abstract = "Neuner et al. describe the generation and validation of the AD-BXDs, the first reproducible set of AD mouse models incorporating genetic diversity. These models recapitulate aspects of human AD and provide a new resource to identify genes and pathways associated with risk and resilience to AD.",

keywords = "5XFAD, Alzheimer's, BXD, amyloid, genetic diversity, genetic risk score, mouse models, resilience, susceptibility, translational",

author = "Neuner, {Sarah M.} and Heuer, {Sarah E.} and Huentelman, {Matthew J.} and O'Connell, {Kristen M.S.} and Kaczorowski, {Catherine C.}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2019",

month = feb,

day = "6",

doi = "10.1016/j.neuron.2018.11.040",

language = "English",

volume = "101",

pages = "399--411.e5",

journal = "Neuron",

issn = "0896-6273",

publisher = "Cell Press",

number = "3",

}

TY - JOUR

T1 - Harnessing Genetic Complexity to Enhance Translatability of Alzheimer's Disease Mouse Models

T2 - A Path toward Precision Medicine

AU - Neuner, Sarah M.

AU - Heuer, Sarah E.

AU - Huentelman, Matthew J.

AU - O'Connell, Kristen M.S.

AU - Kaczorowski, Catherine C.

PY - 2019/2/6

Y1 - 2019/2/6

N2 - Neuner et al. describe the generation and validation of the AD-BXDs, the first reproducible set of AD mouse models incorporating genetic diversity. These models recapitulate aspects of human AD and provide a new resource to identify genes and pathways associated with risk and resilience to AD.

AB - Neuner et al. describe the generation and validation of the AD-BXDs, the first reproducible set of AD mouse models incorporating genetic diversity. These models recapitulate aspects of human AD and provide a new resource to identify genes and pathways associated with risk and resilience to AD.

KW - 5XFAD

KW - Alzheimer's

KW - BXD

KW - amyloid

KW - genetic diversity

KW - genetic risk score

KW - mouse models

KW - resilience

KW - susceptibility

KW - translational

UR - http://www.scopus.com/inward/record.url?scp=85060856092&partnerID=8YFLogxK

U2 - 10.1016/j.neuron.2018.11.040

DO - 10.1016/j.neuron.2018.11.040

M3 - Article

C2 - 30595332

AN - SCOPUS:85060856092

SN - 0896-6273

VL - 101

SP - 399-411.e5

JO - Neuron

JF - Neuron

IS - 3

ER -

Harnessing Genetic Complexity to Enhance Translatability of Alzheimer's Disease Mouse Models: A Path toward Precision Medicine

Abstract

Keywords

Access to Document

Fingerprint

Cite this