Harnessing Genetic Complexity to Enhance Translatability of Alzheimer's Disease Mouse Models: A Path toward Precision Medicine

Sarah M. Neuner, Sarah E. Heuer, Matthew J. Huentelman, Kristen M.S. O'Connell, Catherine C. Kaczorowski

Research output: Contribution to journalArticlepeer-review

88 Scopus citations

Abstract

Neuner et al. describe the generation and validation of the AD-BXDs, the first reproducible set of AD mouse models incorporating genetic diversity. These models recapitulate aspects of human AD and provide a new resource to identify genes and pathways associated with risk and resilience to AD.

Original languageEnglish
Pages (from-to)399-411.e5
JournalNeuron
Volume101
Issue number3
DOIs
StatePublished - 6 Feb 2019
Externally publishedYes

Keywords

  • 5XFAD
  • Alzheimer's
  • BXD
  • amyloid
  • genetic diversity
  • genetic risk score
  • mouse models
  • resilience
  • susceptibility
  • translational

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