Haploidentical peripheral blood stem cell infusion in combination with chemotherapy for acute myeloid leukaemia in elderly patients

D. C. Bishop, A. J. Johnston, J. M.W. Kwan, V. Antonenas, David J. Gottlieb

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Elderly patients with acute myeloid leukaemia (AML) have a poor prognosis with standard chemotherapy. Two elderly AML patients treated with infusion of family-derived partially human leukocyte antigen (HLA)-matched peripheral blood stem cells following each cycle of chemotherapy entered morphological complete remission without graft versus host disease or major toxicity. Our results support this as a non-toxic approach for inducing a graft versus leukaemia effect in patients not suitable for allogeneic transplantation. Additional resources required for donor assessment and harvest may be reduced by using banked partially HLA-matched mononuclear cells from unrelated donors.

Original languageEnglish
Pages (from-to)1038-1040
Number of pages3
JournalInternal Medicine Journal
Volume44
Issue number10
DOIs
StatePublished - 1 Oct 2014
Externally publishedYes

Keywords

  • Acute myeloid leukaemia
  • Adoptive cellular immunotherapy
  • Aged
  • Antineoplastic combined chemotherapy protocol/therapeutic use
  • Hematopoietic stem cell transplantation

Fingerprint

Dive into the research topics of 'Haploidentical peripheral blood stem cell infusion in combination with chemotherapy for acute myeloid leukaemia in elderly patients'. Together they form a unique fingerprint.

Cite this