Hamilton-jacobi skeletons on cortical surfaces with applications in characterizing the gyrification pattern in williams syndrome

Yonggang Shi, Allan L. Reiss, Agatha D. Lee, Rebecca A. Dutton, Ursula Bellugi, Albert M. Galaburda, Julie R. Korenberg, Debra L. Mills, Ivo Dinov, Paul M. Thompson, Arthur W. Toga

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

3 Scopus citations

Abstract

We propose in this paper a novel approach for the automatic detection of sulcal lines on cortical surfaces as the skeleton of sulcal regions. As a first step, we partition a cortical surface into sulcal and gyral regions by using graph cuts to guarantee a global minimum for an associated variational optimization problem. The Hamilton-Jacobi skeleton method is then extended to subsets of triangular meshes using geodesic distance transforms obtained with the fast marching algorithm on triangular meshes. By decomposing the resulting skeleton into branches, we also develop an alternative approach to measure the complexity of the gyrification pattern of the cortex. In our experiments, we apply our method to a group of 40 healthy controls and 42 subjects with Williams syndrome. We report statistically significant group differences that validate previous findings of an increase in cortical complexity in Williams syndrome.

Original languageEnglish
Title of host publication2007 4th IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro - Proceedings
Pages660-663
Number of pages4
DOIs
StatePublished - 2007
Externally publishedYes
Event2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro; ISBI'07 - Arlington, VA, United States
Duration: 12 Apr 200715 Apr 2007

Publication series

Name2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings

Conference

Conference2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro; ISBI'07
Country/TerritoryUnited States
CityArlington, VA
Period12/04/0715/04/07

Keywords

  • Cortex
  • Graph cut
  • Gyrification
  • Skeleton
  • Williams syndrome

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