Hallazgos En Tomografía Computada Multidetector En El Diagnóstico Del Carcinoma Hepatocelular En Pacientes Con Cirrosis Y Su Correlación Con La Anatomía Patológica Del Explante Hepático

Translated title of the contribution: Findings in multidetector computed tomography in the diagnosis of hepatocellular carcinoma in patients with cirrhosis and correlation with pathology of liver explants

D. Haberman, M. Castignola, M. Mela, H. Paladini, J. P. Santilli, F. Gruz, G. Gondolesi

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Objectives: To describe the imagenological behavior of hepatocellular carcinoma in cirrhotic patients using a dynamic multidetector computed tomography (MDCT) technique, and correlate these findings with histological tumor grades. Materials and methods: A retrospective, descriptive observational study was conducted to evaluate 51 nodules in 32 liver transplant patients diagnosed with liver cirrhosis. The pathology of liver explants was used as a reference. Nodules with hepatocellular carcinoma histopathology were retrospectively analyzed by computed tomography scans performed pre-Transplant. Using a dynamic multidetector computed tomography technique, we evaluated the most common imagenological behavior reported in the literature: arterial enhancement, washout, capsule, and intratumoral arterial vessels. Results: Forty-six of 51 (90%) tumors showed arterial enhancement. Of the 46 tumors with arterial enhancement, 39 (85%) had washout in portal-late phase. Five of 51 (10%) were hypovascular. Twenty-Two of 51 (43%) had capsule and 12 of 51 (24%) showed intratumoral arterial vessels. The more frequent image combination was the combination of arterial enhancement and washout (39 of 51 tumors or 76%). The most frequent histological grade was II (35 of 51 tumors or 69%). Statistically significant relationships were found between histological grade tumors and imagenological behavior: arterial enhancement and hypovascular. Conclusion: In our population, arterial enhancement with washout in portal-late phases was observed in most of the tumors. Our results are consistent with previously reported studies, demonstrating the high reliability of this imaging pattern for the diagnosis of hepatocellular carcinoma.

Translated title of the contributionFindings in multidetector computed tomography in the diagnosis of hepatocellular carcinoma in patients with cirrhosis and correlation with pathology of liver explants
Original languageSpanish
Pages (from-to)209-217
Number of pages9
JournalRevista Argentina de Radiologia
Volume77
Issue number3
DOIs
StatePublished - 2013
Externally publishedYes

Keywords

  • Cirrhosis
  • Dynamic multidetector computed tomography
  • Hepatocellular carcinoma

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