Hairless promotes PPARγ expression and is required for white adipogenesis

Susann Kumpf; Michael Mihlan; Alexander Goginashvili; Gerald Grandl; Helmuth Gehart; Aurélie Godel; Juliane Schmidt; Julius Müller; Marco Bezzi; Arne Ittner; Ernesto Guccione; Christian Wolfrum; Romeo Ricci

doi:10.1038/embor.2012.133

Hairless promotes PPARγ expression and is required for white adipogenesis

Susann Kumpf, Michael Mihlan, Alexander Goginashvili, Gerald Grandl, Helmuth Gehart, Aurélie Godel, Juliane Schmidt, Julius Müller, Marco Bezzi, Arne Ittner, Ernesto Guccione, Christian Wolfrum, Romeo Ricci

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Adipose tissue is the largest compartment in the mammalian body for storing energy as fat, providing an important reservoir of fuel for maintaining whole body energy homeostasis. Herein, we identify the transcriptional cofactor hairless (HR) to be required for white adipogenesis. Moreover, forced expression of HR in non-Adipogenic precursor cells induces adipogenic gene expression and enhances adipocyte formation under permissive conditions. HR exerts its proadipogenic effects by regulating the expression of PPARγ, one of the central adipogenic transcription factors. In conclusion, our data provide a new mechanism required for white adipogenesis.

Original language	English
Pages (from-to)	1012-1020
Number of pages	9
Journal	EMBO Reports
Volume	13
Issue number	11
DOIs	https://doi.org/10.1038/embor.2012.133
State	Published - Nov 2012
Externally published	Yes

Keywords

JmjC
PPARγ
adipogenesis
hairless
obesity

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10.1038/embor.2012.133

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abstract = "Adipose tissue is the largest compartment in the mammalian body for storing energy as fat, providing an important reservoir of fuel for maintaining whole body energy homeostasis. Herein, we identify the transcriptional cofactor hairless (HR) to be required for white adipogenesis. Moreover, forced expression of HR in non-Adipogenic precursor cells induces adipogenic gene expression and enhances adipocyte formation under permissive conditions. HR exerts its proadipogenic effects by regulating the expression of PPARγ, one of the central adipogenic transcription factors. In conclusion, our data provide a new mechanism required for white adipogenesis.",

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T1 - Hairless promotes PPARγ expression and is required for white adipogenesis

AU - Kumpf, Susann

AU - Mihlan, Michael

AU - Goginashvili, Alexander

AU - Grandl, Gerald

AU - Gehart, Helmuth

AU - Godel, Aurélie

AU - Schmidt, Juliane

AU - Müller, Julius

AU - Bezzi, Marco

AU - Ittner, Arne

AU - Guccione, Ernesto

AU - Wolfrum, Christian

AU - Ricci, Romeo

PY - 2012/11

Y1 - 2012/11

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AB - Adipose tissue is the largest compartment in the mammalian body for storing energy as fat, providing an important reservoir of fuel for maintaining whole body energy homeostasis. Herein, we identify the transcriptional cofactor hairless (HR) to be required for white adipogenesis. Moreover, forced expression of HR in non-Adipogenic precursor cells induces adipogenic gene expression and enhances adipocyte formation under permissive conditions. HR exerts its proadipogenic effects by regulating the expression of PPARγ, one of the central adipogenic transcription factors. In conclusion, our data provide a new mechanism required for white adipogenesis.

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KW - obesity

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Hairless promotes PPARγ expression and is required for white adipogenesis

Abstract

Keywords

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