Habenular synapses and nicotine

Jessica L. Ables; Beatriz Antolin-Fontes; Ines Ibañez-Tallon

doi:10.1016/B978-0-12-813035-3.00010-1

Habenular synapses and nicotine

Jessica L. Ables, Beatriz Antolin-Fontes, Ines Ibañez-Tallon

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

Abstract

The adaptive changes produced by repeated exposure to nicotine play a crucial role in the establishment of dependence. While many brain areas are enriched in nicotinic acetylcholine receptors (nAChRs) and participate in the addictive effects of nicotine, recently, the habenular circuit, which is highly enriched in a3Β4a5 nAChRs, has emerged as a critical node for acquisition of nicotine intake and difficulties in smoking cessation. This book chapter will review the anatomical and functional connections of the medial habenula-interpeduncular nucleus (MHb-IPN) circuit and the unique molecular and electrophysiological properties of habenular synapses that underlie the neuroadaptive changes that occur in response to chronic nicotine.

Original language	English
Title of host publication	Neuroscience of Nicotine
Subtitle of host publication	Mechanisms and Treatment
Publisher	Elsevier
Pages	71-78
Number of pages	8
ISBN (Electronic)	9780128130353
ISBN (Print)	9780128130360
DOIs	https://doi.org/10.1016/B978-0-12-813035-3.00010-1
State	Published - 1 Jan 2019

Keywords

ACh-glutamate corelease
Habenula-IPN
Nicotine dependence
Presynaptic facilitation
Vesicular synergy
nAChRs

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10.1016/B978-0-12-813035-3.00010-1

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AU - Antolin-Fontes, Beatriz

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AB - The adaptive changes produced by repeated exposure to nicotine play a crucial role in the establishment of dependence. While many brain areas are enriched in nicotinic acetylcholine receptors (nAChRs) and participate in the addictive effects of nicotine, recently, the habenular circuit, which is highly enriched in a3Β4a5 nAChRs, has emerged as a critical node for acquisition of nicotine intake and difficulties in smoking cessation. This book chapter will review the anatomical and functional connections of the medial habenula-interpeduncular nucleus (MHb-IPN) circuit and the unique molecular and electrophysiological properties of habenular synapses that underlie the neuroadaptive changes that occur in response to chronic nicotine.

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KW - Presynaptic facilitation

KW - Vesicular synergy

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Habenular synapses and nicotine

Abstract

Keywords

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