Habenular synapses and nicotine

Jessica L. Ables, Beatriz Antolin-Fontes, Ines Ibañez-Tallon

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations


The adaptive changes produced by repeated exposure to nicotine play a crucial role in the establishment of dependence. While many brain areas are enriched in nicotinic acetylcholine receptors (nAChRs) and participate in the addictive effects of nicotine, recently, the habenular circuit, which is highly enriched in a3Β4a5 nAChRs, has emerged as a critical node for acquisition of nicotine intake and difficulties in smoking cessation. This book chapter will review the anatomical and functional connections of the medial habenula-interpeduncular nucleus (MHb-IPN) circuit and the unique molecular and electrophysiological properties of habenular synapses that underlie the neuroadaptive changes that occur in response to chronic nicotine.

Original languageEnglish
Title of host publicationNeuroscience of Nicotine
Subtitle of host publicationMechanisms and Treatment
Number of pages8
ISBN (Electronic)9780128130353
ISBN (Print)9780128130360
StatePublished - 1 Jan 2019


  • ACh-glutamate corelease
  • Habenula-IPN
  • Nicotine dependence
  • Presynaptic facilitation
  • Vesicular synergy
  • nAChRs


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