H7N9 influenza viruses are transmissible in ferrets by respiratory droplet

Qianyi Zhang; Jianzhong Shi; Guohua Deng; Jing Guo; Xianying Zeng; Xijun He; Huihui Kong; Chunyang Gu; Xuyong Li; Jinxiong Liu; Guojun Wang; Yan Chen; Liling Liu; Libin Liang; Yuanyuan Li; Jun Fan; Jinliang Wang; Wenhui Li; Lizheng Guan; Qimeng Li; Huanliang Yang; Pucheng Chen; Li Jiang; Yuntao Guan; Xiaoguang Xin; Yongping Jiang; Guobin Tian; Xiurong Wang; Chuanling Qiao; Chengjun Li; Zhigao Bu; Hualan Chen

doi:10.1126/science.1240532

H7N9 influenza viruses are transmissible in ferrets by respiratory droplet

Qianyi Zhang, Jianzhong Shi, Guohua Deng, Jing Guo, Xianying Zeng, Xijun He, Huihui Kong, Chunyang Gu, Xuyong Li, Jinxiong Liu, Guojun Wang, Yan Chen, Liling Liu, Libin Liang, Yuanyuan Li, Jun Fan, Jinliang Wang, Wenhui Li, Lizheng Guan, Qimeng LiHuanliang Yang, Pucheng Chen, Li Jiang, Yuntao Guan, Xiaoguang Xin, Yongping Jiang, Guobin Tian, Xiurong Wang, Chuanling Qiao, Chengjun Li, Zhigao Bu, Hualan Chen

Research output: Contribution to journal › Article › peer-review

356 Scopus citations

Abstract

A newly emerged H7N9 virus has caused 132 human infections with 37 deaths in China since 18 February 2013. Control measures in H7N9 virus-positive live poultry markets have reduced the number of infections; however, the character of the virus, including its pandemic potential, remains largely unknown. We systematically analyzed H7N9 viruses isolated from birds and humans. The viruses were genetically closely related and bound to human airway receptors; some also maintained the ability to bind to avian airway receptors. The viruses isolated from birds were nonpathogenic in chickens, ducks, and mice; however, the viruses isolated from humans caused up to 30% body weight loss in mice. Most importantly, one virus isolated from humans was highly transmissible in ferrets by respiratory droplet. Our findings indicate nothing to reduce the concern that these viruses can transmit between humans.

Original language	English
Pages (from-to)	410-414
Number of pages	5
Journal	Science
Volume	341
Issue number	6144
DOIs	https://doi.org/10.1126/science.1240532
State	Published - 2013
Externally published	Yes

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@article{e9f84a7fa4bd4fd5865e223f3485d360,

title = "H7N9 influenza viruses are transmissible in ferrets by respiratory droplet",

abstract = "A newly emerged H7N9 virus has caused 132 human infections with 37 deaths in China since 18 February 2013. Control measures in H7N9 virus-positive live poultry markets have reduced the number of infections; however, the character of the virus, including its pandemic potential, remains largely unknown. We systematically analyzed H7N9 viruses isolated from birds and humans. The viruses were genetically closely related and bound to human airway receptors; some also maintained the ability to bind to avian airway receptors. The viruses isolated from birds were nonpathogenic in chickens, ducks, and mice; however, the viruses isolated from humans caused up to 30% body weight loss in mice. Most importantly, one virus isolated from humans was highly transmissible in ferrets by respiratory droplet. Our findings indicate nothing to reduce the concern that these viruses can transmit between humans.",

author = "Qianyi Zhang and Jianzhong Shi and Guohua Deng and Jing Guo and Xianying Zeng and Xijun He and Huihui Kong and Chunyang Gu and Xuyong Li and Jinxiong Liu and Guojun Wang and Yan Chen and Liling Liu and Libin Liang and Yuanyuan Li and Jun Fan and Jinliang Wang and Wenhui Li and Lizheng Guan and Qimeng Li and Huanliang Yang and Pucheng Chen and Li Jiang and Yuntao Guan and Xiaoguang Xin and Yongping Jiang and Guobin Tian and Xiurong Wang and Chuanling Qiao and Chengjun Li and Zhigao Bu and Hualan Chen",

year = "2013",

doi = "10.1126/science.1240532",

language = "English",

volume = "341",

pages = "410--414",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6144",

}

Zhang, Q, Shi, J, Deng, G, Guo, J, Zeng, X, He, X, Kong, H, Gu, C, Li, X, Liu, J, Wang, G, Chen, Y, Liu, L, Liang, L, Li, Y, Fan, J, Wang, J, Li, W, Guan, L, Li, Q, Yang, H, Chen, P, Jiang, L, Guan, Y, Xin, X, Jiang, Y, Tian, G, Wang, X, Qiao, C, Li, C, Bu, Z & Chen, H 2013, 'H7N9 influenza viruses are transmissible in ferrets by respiratory droplet', Science, vol. 341, no. 6144, pp. 410-414. https://doi.org/10.1126/science.1240532

TY - JOUR

T1 - H7N9 influenza viruses are transmissible in ferrets by respiratory droplet

AU - Zhang, Qianyi

AU - Shi, Jianzhong

AU - Deng, Guohua

AU - Guo, Jing

AU - Zeng, Xianying

AU - He, Xijun

AU - Kong, Huihui

AU - Gu, Chunyang

AU - Li, Xuyong

AU - Liu, Jinxiong

AU - Wang, Guojun

AU - Chen, Yan

AU - Liu, Liling

AU - Liang, Libin

AU - Li, Yuanyuan

AU - Fan, Jun

AU - Wang, Jinliang

AU - Li, Wenhui

AU - Guan, Lizheng

AU - Li, Qimeng

AU - Yang, Huanliang

AU - Chen, Pucheng

AU - Jiang, Li

AU - Guan, Yuntao

AU - Xin, Xiaoguang

AU - Jiang, Yongping

AU - Tian, Guobin

AU - Wang, Xiurong

AU - Qiao, Chuanling

AU - Li, Chengjun

AU - Bu, Zhigao

AU - Chen, Hualan

PY - 2013

Y1 - 2013

N2 - A newly emerged H7N9 virus has caused 132 human infections with 37 deaths in China since 18 February 2013. Control measures in H7N9 virus-positive live poultry markets have reduced the number of infections; however, the character of the virus, including its pandemic potential, remains largely unknown. We systematically analyzed H7N9 viruses isolated from birds and humans. The viruses were genetically closely related and bound to human airway receptors; some also maintained the ability to bind to avian airway receptors. The viruses isolated from birds were nonpathogenic in chickens, ducks, and mice; however, the viruses isolated from humans caused up to 30% body weight loss in mice. Most importantly, one virus isolated from humans was highly transmissible in ferrets by respiratory droplet. Our findings indicate nothing to reduce the concern that these viruses can transmit between humans.

AB - A newly emerged H7N9 virus has caused 132 human infections with 37 deaths in China since 18 February 2013. Control measures in H7N9 virus-positive live poultry markets have reduced the number of infections; however, the character of the virus, including its pandemic potential, remains largely unknown. We systematically analyzed H7N9 viruses isolated from birds and humans. The viruses were genetically closely related and bound to human airway receptors; some also maintained the ability to bind to avian airway receptors. The viruses isolated from birds were nonpathogenic in chickens, ducks, and mice; however, the viruses isolated from humans caused up to 30% body weight loss in mice. Most importantly, one virus isolated from humans was highly transmissible in ferrets by respiratory droplet. Our findings indicate nothing to reduce the concern that these viruses can transmit between humans.

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U2 - 10.1126/science.1240532

DO - 10.1126/science.1240532

M3 - Article

AN - SCOPUS:84880713109

SN - 0036-8075

VL - 341

SP - 410

EP - 414

JO - Science

JF - Science

IS - 6144

ER -

H7N9 influenza viruses are transmissible in ferrets by respiratory droplet

Abstract

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