TY - JOUR
T1 - Gut microbiota density influences host physiology and is shaped by host and microbial factors
AU - Contijoch, Eduardo J.
AU - Britton, Graham J.
AU - Yang, Chao
AU - Mogno, Ilaria
AU - Li, Zhihua
AU - Ng, Ruby
AU - Llewellyn, Sean R.
AU - Hira, Sheela
AU - Johnson, Crystal
AU - Rabinowitz, Keren M.
AU - Barkan, Revital
AU - Dotan, Iris
AU - Hirten, Robert P.
AU - Fu, Shih Chen
AU - Luo, Yuying
AU - Yang, Nancy
AU - Luong, Tramy
AU - Labrias, Philippe R.
AU - Lira, Sergio
AU - Peter, Inga
AU - Grinspan, Ari
AU - Clemente, Jose C.
AU - Kosoy, Roman
AU - Kim-Schulze, Seunghee
AU - Qin, Xiaochen
AU - Castillo, Anabella
AU - Hurley, Amanda
AU - Atreja, Ashish
AU - Rogers, Jason
AU - Fasihuddin, Farah
AU - Saliaj, Merjona
AU - Nolan, Amy
AU - Reyes-Mercedes, Pamela
AU - Rodriguez, Carina
AU - Aly, Sarah
AU - Santa-Cruz, Kenneth
AU - Peters, Lauren
AU - Suárez-Fariñas, Mayte
AU - Huang, Ruiqi
AU - Hao, Ke
AU - Zhu, Jun
AU - Zhang, Bin
AU - Losic, Bojan
AU - Irizar, Haritz
AU - Song, Won Min
AU - Narzo, Antonio Di
AU - Wang, Wenhui
AU - Cohen, Benjamin L.
AU - Dimaio, Christopher
AU - Greenwald, David
AU - Itzkowitz, Steven
AU - Lucas, Aimee
AU - Marion, James
AU - Maser, Elana
AU - Ungaro, Ryan
AU - Naymagon, Steven
AU - Novak, Joshua
AU - Shah, Brijen
AU - Ullman, Thomas
AU - Rubin, Peter
AU - George, James
AU - Legnani, Peter
AU - Telesco, Shannon E.
AU - Friedman, Joshua R.
AU - Brodmerkel, Carrie
AU - Plevy, Scott
AU - Cho, Judy H.
AU - Colombel, Jean Frederic
AU - Schadt, Eric E.
AU - Argmann, Carmen
AU - Dubinsky, Marla
AU - Kasarskis, Andrew
AU - Sands, Bruce
AU - Faith, Jeremiah J.
N1 - Publisher Copyright:
© 2019, eLife Sciences Publications Ltd. All rights reserved.
PY - 2019
Y1 - 2019
N2 - To identify factors that regulate gut microbiota density and the impact of varied microbiota density on health, we assayed this fundamental ecosystem property in fecal samples across mammals, human disease, and therapeutic interventions. Physiologic features of the host (carrying capacity) and the fitness of the gut microbiota shape microbiota density. Therapeutic manipulation of microbiota density in mice altered host metabolic and immune homeostasis. In humans, gut microbiota density was reduced in Crohn’s disease, ulcerative colitis, and ileal pouch-anal anastomosis. The gut microbiota in recurrent Clostridium difficile infection had lower density and reduced fitness that were restored by fecal microbiota transplantation. Understanding the interplay between microbiota and disease in terms of microbiota density, host carrying capacity, and microbiota fitness provide new insights into microbiome structure and microbiome targeted therapeutics.
AB - To identify factors that regulate gut microbiota density and the impact of varied microbiota density on health, we assayed this fundamental ecosystem property in fecal samples across mammals, human disease, and therapeutic interventions. Physiologic features of the host (carrying capacity) and the fitness of the gut microbiota shape microbiota density. Therapeutic manipulation of microbiota density in mice altered host metabolic and immune homeostasis. In humans, gut microbiota density was reduced in Crohn’s disease, ulcerative colitis, and ileal pouch-anal anastomosis. The gut microbiota in recurrent Clostridium difficile infection had lower density and reduced fitness that were restored by fecal microbiota transplantation. Understanding the interplay between microbiota and disease in terms of microbiota density, host carrying capacity, and microbiota fitness provide new insights into microbiome structure and microbiome targeted therapeutics.
UR - http://www.scopus.com/inward/record.url?scp=85060214409&partnerID=8YFLogxK
U2 - 10.7554/eLife.40553
DO - 10.7554/eLife.40553
M3 - Article
C2 - 30666957
AN - SCOPUS:85060214409
SN - 2050-084X
VL - 8
JO - eLife
JF - eLife
M1 - e40553
ER -