Guinea pig pancreatic polypeptide: Structure and pancreatic content

J. Eng, C. G. Huang, Y. C.E. Pan, J. D. Hulmes, R. S. Yalow

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Guinea pig (GP) pancreatic polypeptide (PP) has been purified from an acid-alcohol extract of 6 GP pancreata by a series of 3 HLPC steps. The sequence for GP PP as compared with that of beef and human is shown: GP A P L E P V Y P G D D A T P Q Q MA Q Y A A E MR R Y I N ML T R P R Y Beef A P L E P E Y P G D N A T P E Q MA Q Y A A E L R R Y I N ML T R P R Y Human A P L E P V Y P G D N A T P E Q MA Q Y A A D L R R Y I N ML T R P R Y. In a single GP pancreas weighing 2.4 g the total PP content was 1.0 nmol and the total glucagon content 61 nmol; in a single dog pancreas weighing 35 g the total PP was 385 nmol and the total glucagon 81 nmol. The relatively low content of PP in GP pancreas is consistent with the fact that the GP lacks a ventral pancreas, the region in which PP is found in highest concentration. The high glucagon content of GP pancreas is consistent with that reported in earlier studies.

Original languageEnglish
Pages (from-to)165-168
Number of pages4
JournalPeptides
Volume8
Issue number1
DOIs
StatePublished - 1987
Externally publishedYes

Keywords

  • Amino acid sequence
  • Guinea pig pancreatic polypeptide purification
  • Pancreatic content of glucagon
  • Pancreatic content of pancreatic polypeptide

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