Guidelines for the effective use of chemical inhibitors of protein function to understand their roles in cell regulation

Philip Cohen

doi:10.1042/BJ20091428

Guidelines for the effective use of chemical inhibitors of protein function to understand their roles in cell regulation

Philip Cohen

Research output: Contribution to journal › Review article › peer-review

60 Scopus citations

Abstract

Cell-permeable chemical inhibitors have become invaluable reagents for the study of cellular regulation. In the present paper, using protein kinase inhibitors as the example, a set of criteria are described that should be met before any investigation using such compounds should be accepted for publication.

Original language	English
Pages (from-to)	53-54
Number of pages	2
Journal	Biochemical Journal
Volume	425
Issue number	1
DOIs	https://doi.org/10.1042/BJ20091428
State	Published - 1 Jan 2010
Externally published	Yes

Keywords

Cell regulation
Chemical biology
Chemical inhibitor
Protein kinase
Signal transduction

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10.1042/BJ20091428

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abstract = "Cell-permeable chemical inhibitors have become invaluable reagents for the study of cellular regulation. In the present paper, using protein kinase inhibitors as the example, a set of criteria are described that should be met before any investigation using such compounds should be accepted for publication.",

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KW - Chemical inhibitor

KW - Protein kinase

KW - Signal transduction

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DO - 10.1042/BJ20091428

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Guidelines for the effective use of chemical inhibitors of protein function to understand their roles in cell regulation

Abstract

Keywords

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