GST function in drug and stress response

Kenneth D. Tew, Ze'ev Ronai

Research output: Contribution to journalReview articlepeer-review

98 Scopus citations

Abstract

Glutathione (GSH) is the major non-protein thiol in cells and is a co- factor for many types of conjugation reactions involving glutathione S- transferases (GST). Because of the defined role of GST in drug metabolism, elevated expression of GSTπ either as a tumor marker or in drug resistance has automatically been linked to detoxification. Similarly, GSH has mostly been viewed as a passive cellular supply of nucleophilic sulfur. This mini- review highlights recent reports which advocate a novel, non-catalytic role for GSTπ as an integral determinant of cellular pathways of stress response, proliferation and apoptosis.

Original languageEnglish
Pages (from-to)143-147
Number of pages5
JournalDrug Resistance Updates
Volume2
Issue number3
DOIs
StatePublished - Jun 1999

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