Growth of human bone marrow in vitro

I. Svet-Moldavsky, S. C. Gulati, B. Clarkson

Research output: Contribution to journalArticlepeer-review


Attempts were made to establish human bone marrow (HBM) culture. Cell proliferation was triggered by medium conditioned by acute myelocytic leukemic (AML) cells exposed to 12-O-tetradecanoyl-phorbol-13-acetate (TPA). A 6-15 fold multiplication of myelomonocytic cells was obtained in tissue culture from HBM cells. Proliferation of granulocyte-macrophage colony forming cells (CFC-GM) occurred up to 30-fold. The morphology of the cells and cytochemical markers were investigated at all stages of the culture.

Original languageEnglish
Pages (from-to)833-840
Number of pages8
JournalCell Biology International Reports
Issue number9
StatePublished - Sep 1985
Externally publishedYes


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