Growth hormone response to clonidine in obsessive-compulsive patients

L. J. Siever, T. R. Insel, D. C. Jimerson, C. R. Lake, T. W. Uhde, J. Aloi, D. L. Murphy

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

We have observed a lesser growth hormone response to intravenous clonidine administration in nine obsessive-compulsive disorder patients meeting research diagnostic criteria than in nine matched controls. The obsessive-compulsive disorder patients had higher plasma free 3-methoxy-4-hydroxyphenylglycol and plasma norepinephrine levels before clonidine than the controls. As blunted growth hormone responses to clonidine are also characteristic of affective disorder patients, these results support other observations of a psychobiologic affinity between these two groups and are also compatible with an association between increased presynaptic noradrenergic activity and decreased post-synaptic receptor responsiveness.

Original languageEnglish
Pages (from-to)184-187
Number of pages4
JournalUnknown Journal
Volume142
Issue number2
DOIs
StatePublished - 1983
Externally publishedYes

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